User profiles for Ilaria Marinoni
 | ilaria marinoniGroup Leader, University of Bern Verified email at pathology.unibe.ch Cited by 1791 |
Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors
Background & Aims Sporadic pancreatic neuroendocrine tumors (pNETs) are rare and
genetically heterogeneous. Chromosome instability (CIN) has been detected in pNETs from …
genetically heterogeneous. Chromosome instability (CIN) has been detected in pNETs from …
[HTML][HTML] Genetic and epigenetic drivers of neuroendocrine tumours (NET)
A Di Domenico, T Wiedmer, I Marinoni… - Endocrine-related …, 2017 - erc.bioscientifica.com
Neuroendocrine tumours (NET) of the gastrointestinal tract and the lung are a rare and
heterogeneous group of tumours. The molecular characterization and the clinical classification of …
heterogeneous group of tumours. The molecular characterization and the clinical classification of …
Somatic Mutation and Germline Sequence Abnormalities in CDKN1B, Encoding p27Kip1, in Sporadic Parathyroid Adenomas
J Costa-Guda, I Marinoni, S Molatore… - The Journal of …, 2011 - academic.oup.com
Context: Typical nonfamilial (sporadic) parathyroid adenomas are common endocrine tumors
for which no predisposing germline DNA variants and only a few clonally altered genes …
for which no predisposing germline DNA variants and only a few clonally altered genes …
A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization
S Molatore, I Marinoni, M Lee, E Pulz… - Human …, 2010 - Wiley Online Library
Multiple endocrine neoplasia (MEN) syndromes are characterized by tumors involving two
or more endocrine glands. Two MEN syndromes have long been known: MEN1 and MEN2, …
or more endocrine glands. Two MEN syndromes have long been known: MEN1 and MEN2, …
[HTML][HTML] Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression
Recent data suggest that Pancreatic Neuroendocrine Tumours (PanNETs) originate from α-
or β-cells of the islets of Langerhans. The majority of PanNETs are non-functional and do not …
or β-cells of the islets of Langerhans. The majority of PanNETs are non-functional and do not …
Competitive testing of the WHO 2010 versus the WHO 2017 grading of pancreatic neuroendocrine neoplasms: data from a large international cohort study
…, S La Rosa, RT Lawlor, TV Luong, I Marinoni… - …, 2019 - karger.com
Background: The World Health Organization (WHO) and the American Joint Cancer Committee
(AJCC) modified the grading of pancreatic neuroendocrine neoplasms from a three-tier (…
(AJCC) modified the grading of pancreatic neuroendocrine neoplasms from a three-tier (…
[HTML][HTML] Cyclin-dependent kinase inhibitor 1B (CDKN1B) gene variants in AIP mutation-negative familial isolated pituitary adenoma kindreds
Familial isolated pituitary adenoma (FIPA) occurs in families and is unrelated to multiple
endocrine neoplasia type 1 and Carney complex. Mutations in AIP account only for 15–25% of …
endocrine neoplasia type 1 and Carney complex. Mutations in AIP account only for 15–25% of …
Autophagy inhibition improves sunitinib efficacy in pancreatic neuroendocrine tumors via a lysosome-dependent mechanism
Increasing the efficacy of approved systemic treatments in metastasized pancreatic
neuroendocrine tumors (PanNET) is an unmet medical need. The antiangiogenic tyrosine kinase …
neuroendocrine tumors (PanNET) is an unmet medical need. The antiangiogenic tyrosine kinase …
Three-dimensional primary cell culture: a novel preclinical model for pancreatic neuroendocrine tumors
Molecular mechanisms underlying the development and progression of pancreatic
neuroendocrine tumors (PanNETs) are still insufficiently understood. Efficacy of currently approved …
neuroendocrine tumors (PanNETs) are still insufficiently understood. Efficacy of currently approved …
Treatment of advanced gastroenteropancreatic neuroendocrine neoplasia, are we on the way to personalised medicine?
Gastroenteropancreatic neuroendocrine neoplasia (GEPNEN) comprises clinically as well
as prognostically diverse tumour entities often diagnosed at late stage. Current classification …
as prognostically diverse tumour entities often diagnosed at late stage. Current classification …