MicroRNAs (miRNAs) regulate the levels of translation of messenger RNAs (mRNAs). At
present, the major parameter that can explain the selection of the target mRNA and the …

The synthesis of eight bifunctional diketopiperazine (DKP) scaffolds is described; these
were formally derived from 2,3‐diaminopropionic acid and aspartic acid (DKP‐1–DKP‐7) or …

Gaining insight into the uptake, trafficking and target engagement of drugs in cells can
enhance understanding of a drug's function and efficiency. However, there are currently no …

The interaction of a small library of cyclic DKP–RGD peptidomimetics with α 5 β 1 integrin
has been investigated by means of an integrated experimental and computational approach. …

Integrins are a large family of heterodimeric transmembrane glycoprotein receptors, composed
of two noncovalently associated α and β subunits.[1] Many integrins, including αvβ3, αvβ5…

NMR experiments (transferred NOE and Saturation Transfer Difference) were used to shed
light on the binding epitope of RGD peptidomimetics 1–3 with integrins αvβ3 and αIIbβ3, …

Understanding the conformational ensembles of intrinsically disordered proteins and
peptides (IDPs) in their various biological environments is essential for understanding their …

Glycodendrimers based on aromatic cores have an amphiphilic character and have been
reported to generate supramolecuar assemblies in water. A new group of glycodendrimers …

microRNAs (miRNAs) regulate target mRNA expression post-transcriptionally through their
association with Argonaute 2 (AGO2) proteins. Predicting the efficiency of mRNA repression …

On a molecular level protein–ligand interactions are central to a number of biological
processes, but their investigation is inherently difficult due to several problems, especially for …