Oligodendrocytes associate with axons to establish myelin and provide metabolic support to
neurons. In the spinal cord of amyotrophic lateral sclerosis (ALS) mice, oligodendrocytes …

The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43)
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …

Astrocyte heterogeneity remains largely unknown in the CNS due to lack of specific astroglial
markers. In this study, molecular identity of in vivo astrocytes was characterized in BAC …

The neuron-astrocyte synaptic complex is a fundamental operational unit of the nervous
system. Astroglia regulate synaptic glutamate, via neurotransmitter transport by GLT1/EAAT2. …

C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis (ALS)/frontotemporal
dementia (FTD) and result in both loss of C9orf72 protein expression and production of …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no
effective treatments. Numerous RNA-binding proteins (RBPs) have been shown to be altered in …

Gangliosides—sialylated glycosphingolipids—are the major glycoconjugates of nerve cells.
The same four structures—GM1, GD1a, GD1b and GT1b—comprise the great majority of …

Amyotrophic lateral sclerosis (ALS) is a synaptopathy accompanied by the presence of
cytoplasmic aggregates containing TDP-43, an RNA-binding protein linked to ∼97% of ALS …

10.7554/eLife.45114.001 Amyotrophic Lateral Sclerosis (ALS), is a fatal neurodegenerative
disorder, with TDP-43 inclusions as a major pathological hallmark. Using a Drosophila …

While motor and cortical neurons are affected in C9orf72 amyotrophic lateral sclerosis and
frontotemporal dementia (ALS/FTD), it remains largely unknown if and how non-neuronal …