A streptococcal protease that degrades CXC chemokines and impairs bacterial clearance from infected tissues

…, I Mishalian, M Dan‐Goor, I Belotserkovsky… - The EMBO …, 2006 - embopress.org
Group A Streptococcus (GAS) causes the life‐threatening infection in humans known as
necrotizing fasciitis (NF). Infected subcutaneous tissues from an NF patient and mice challenged …

[HTML][HTML] Species-targeted sorting and cultivation of commensal bacteria from the gut microbiome using flow cytometry under anaerobic conditions

…, J Baijer, NS Treichel, T Clavel, I Belotserkovsky… - Microbiome, 2022 - Springer
Background There is a growing interest in using gut commensal bacteria as “next generation”
probiotics. However, this approach is still hampered by the fact that there are few or no …

[HTML][HTML] An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation

M Baruch, I Belotserkovsky, BB Hertzog, M Ravins… - Cell, 2014 - cell.com
Successful infection depends on the ability of the pathogen to gain nutrients from the host.
The extracellular pathogenic bacterium group A Streptococcus (GAS) causes a vast array of …

Shigella and Enteroinvasive Escherichia Coli

I Belotserkovsky, PJ Sansonetti - Escherichia coli, a Versatile Pathogen, 2018 - Springer
Shigella and enteroinvasive Escherichia coli (EIEC) are gram-negative bacteria responsible
for bacillary dysentery (shigellosis) in humans, which is characterized by invasion and …

B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection

…, M Neunlist, B Mozeleski, I Belotserkovsky… - Journal of Experimental …, 2014 - rupress.org
Antibody-mediated immunity to Shigella, the causative agent of bacillary dysentery, requires
several episodes of infection to get primed and is short-lasting, suggesting that the B cell …

Transcriptional regulation of the sil locus by the SilCR signalling peptide and its implications on group A streptococcus virulence

…, Y Getter, M Baruch, I Belotserkovsky… - Molecular …, 2007 - Wiley Online Library
In the last two decades an increasing number of local outbreaks of invasive group A streptococcus
(GAS) infections including necrotizing fasciitis (NF) have been reported. We identified …

[HTML][HTML] Functional Analysis of the Quorum-Sensing Streptococcal Invasion Locus (sil)

I Belotserkovsky, M Baruch, A Peer, E Dov… - PLoS …, 2009 - journals.plos.org
Group A streptococcus (GAS) causes a wide variety of human diseases, and at the same
time, GAS can also circulate without producing symptoms, similar to its close commensal …

Glycan-Glycan Interaction Determines Shigella Tropism toward Human T Lymphocytes

I Belotserkovsky, K Brunner, L Pinaud, A Rouvinski… - MBio, 2018 - Am Soc Microbiol
Direct interactions between bacterial and host glycans have been recently reported to be
involved in the binding of pathogenic bacteria to host cells. In the case of Shigella, the Gram-…

Injection of T3SS effectors not resulting in invasion is the main targeting mechanism of Shigella toward human lymphocytes

…, Z Porat, ML Ferrari, I Belotserkovsky… - Proceedings of the …, 2017 - National Acad Sciences
The enteroinvasive bacterium Shigella is a facultative intracellular bacterium known, in vitro,
to invade a large diversity of cells through the delivery of virulence effectors into the cell …

Identification of parameters of host cell vulnerability during Salmonella infection by quantitative image analysis and modeling

J Voznica, C Gardella, I Belotserkovsky… - Infection and …, 2018 - Am Soc Microbiol
Salmonella targets and enters epithelial cells at permissive entry sites: some cells are more
likely to be infected than others. However, the parameters that lead to host cell heterogeneity …