HIV-2 is less pathogenic for humans than HIV-1 and might provide partial cross-protection
from HIV-1-induced pathology. Although both viruses replicate in the T cells of infected …

Cargo partitioning into intralumenal vesicles (ILVs) of multivesicular endosomes underlies
such cellular processes as receptor downregulation, viral budding, and biogenesis of …

Exosomes are small endosome-derived extracellular vesicles implicated in cell–cell
communication and are secreted by living cells when multivesicular bodies (MVBs) fuse with the …

Specialized cells exploit adaptor protein complexes for unique post-Golgi sorting events,
providing a unique model system to specify adaptor function. Here, we show that AP-3 and AP-…

Phagocytosis relies on extension of plasmalemmal pseudopods generated by focal actin
polymerisation and delivery of membranes from intracellular pools. Here we show that …

High-grade serous ovarian cancer (HGSOC) remains an unmet medical challenge. Here,
we unravel an unanticipated metabolic heterogeneity in HGSOC. By combining proteomic, …

Specialized cell types exploit endosomal trafficking to deliver protein cargoes to cell type–specific
lysosome-related organelles (LROs), but how endosomes are specified for this …

Amyloids are often associated with pathologic processes such as in Alzheimer’s disease (AD),
but can also underlie physiological processes such as pigmentation. Formation of …

Important progress has been made during the past decade in the identification of molecular
motors required in the distribution of early and late endosomes and the proper trafficking …

Background To efficiently supply ATP to sites of high-energy demand and finely regulate
calcium signaling, mitochondria adapt their metabolism, shape, and distribution within the cells, …