The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus
I Vandecaetsbeek, P Vangheluwe… - Cold Spring …, 2011 - cshperspectives.cshlp.org
The various splice variants of the three SERCA- and the two SPCA-pump genes in higher
vertebrates encode P-type ATPases of the P 2A group found respectively in the membranes of …
vertebrates encode P-type ATPases of the P 2A group found respectively in the membranes of …
Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump
I Vandecaetsbeek, M Trekels… - Proceedings of the …, 2009 - National Acad Sciences
Sarco(endo)plasmic reticulum Ca 2+ ATPase (SERCA) Ca 2+ transporters pump cytosolic
Ca 2+ into the endoplasmic reticulum, maintaining a Ca 2+ gradient that controls vital cell …
Ca 2+ into the endoplasmic reticulum, maintaining a Ca 2+ gradient that controls vital cell …
Structures of the heart specific SERCA2a Ca2+‐ATPase
…, S Smaardijk, JL Andersen, I Vandecaetsbeek… - The EMBO …, 2019 - embopress.org
The sarcoplasmic/endoplasmic reticulum Ca 2+ ‐ ATP ase 2a ( SERCA 2a) performs active
reuptake of cytoplasmic Ca 2+ and is a major regulator of cardiac muscle contractility. …
reuptake of cytoplasmic Ca 2+ and is a major regulator of cardiac muscle contractility. …
Factors controlling the activity of the SERCA2a pump in the normal and failing heart
I Vandecaetsbeek, L Raeymaekers, F Wuytack… - Biofactors, 2009 - Wiley Online Library
Heart failure is the leading cause of death in western countries and is often associated with
impaired Ca 2+ handling in the cardiomyocyte. In fact, cardiomyocyte relaxation and …
impaired Ca 2+ handling in the cardiomyocyte. In fact, cardiomyocyte relaxation and …
[HTML][HTML] Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca2+/Mn2+-transport ATPase (SPCA1a)
…, JB Hovgaard, S Smaardijk, I Vandecaetsbeek… - Journal of Biological …, 2017 - ASBMB
The Golgi/secretory pathway Ca 2+ /Mn 2+ -transport ATPase (SPCA1a) is implicated in
breast cancer and Hailey-Hailey disease. Here, we purified recombinant human SPCA1a from …
breast cancer and Hailey-Hailey disease. Here, we purified recombinant human SPCA1a from …
[HTML][HTML] An N-terminal Ca2+-binding motif regulates the secretory pathway Ca2+/Mn2+-transport ATPase SPCA1
…, CA Mattelaer, F Pamula, I Vandecaetsbeek… - Journal of Biological …, 2019 - ASBMB
The Ca 2+ /Mn 2+ transport ATPases 1a and 2 (SPCA1a/2) are closely related to the sarco(endo)plasmic
reticulum Ca 2+ -ATPase (SERCA) and are implicated in breast cancer and …
reticulum Ca 2+ -ATPase (SERCA) and are implicated in breast cancer and …
[HTML][HTML] Distinct roles of the C-terminal 11th transmembrane helix and luminal extension in the partial reactions determining the high Ca2+ affinity of sarco (endo) …
JD Clausen, I Vandecaetsbeek, F Wuytack… - Journal of Biological …, 2012 - ASBMB
The molecular mechanism underlying the characteristic high apparent Ca 2+ affinity of
SERCA2b relative to SERCA1a and SERCA2a isoforms was studied. The C-terminal tail of …
SERCA2b relative to SERCA1a and SERCA2a isoforms was studied. The C-terminal tail of …
[HTML][HTML] HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines
H Akl, I Vandecaetsbeek, G Monaco, A Kauskot… - …, 2013 - ncbi.nlm.nih.gov
Many Bcl-2-dependent cancer cells are primed to death due to their upregulation of BH3-only
proteins in response to ongoing oncogenic stress. BH3-mimetic drugs like ABT-737 …
proteins in response to ongoing oncogenic stress. BH3-mimetic drugs like ABT-737 …
[HTML][HTML] Thapsigargin affinity purification of intracellular P2A-type Ca2+ ATPases
I Vandecaetsbeek, SB Christensen, H Liu… - … et Biophysica Acta (BBA …, 2011 - Elsevier
The ubiquitous sarco(endo)plasmic reticulum (SR/ER) Ca 2+ ATPase (SERCA2b) and
secretory-pathway Ca 2+ ATPase (SPCA1a) belong both to the P 2A -type ATPase subgroup of …
secretory-pathway Ca 2+ ATPase (SPCA1a) belong both to the P 2A -type ATPase subgroup of …
[PDF][PDF] Modeling Ca2+ dynamics of mouse cardiac cells points to a critical role of SERCA's affinity for Ca2+
L Raeymaekers, I Vandecaetsbeek, F Wuytack… - Biophysical journal, 2011 - cell.com
The SERCA2a isoform of the sarco/endoplasmic reticulum Ca 2+ pumps is specifically
expressed in the heart, whereas SERCA2b is the ubiquitously expressed variant. It has been …
expressed in the heart, whereas SERCA2b is the ubiquitously expressed variant. It has been …