With the epidemic of human obesity, dietary fats have increasingly become a focal point of
biomedical research. Epidemiological studies indicate that high-fat diets (HFDs), especially …

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability
due to increased free radicals and reduced energy production. In pancreatic cancer cells …

Regeneration of myelin is mediated by oligodendrocyte progenitor cells—an abundant stem
cell population in the central nervous system (CNS) and the principal source of new …

10.7554/eLife.10067.001 The sulfhydration of cysteine residues in proteins is an important
mechanism involved in diverse biological processes. We have developed a proteomics …

The CCAAT/enhancer-binding protein β (C/EBPβ) is required for adipocyte differentiation
and maturation. We have studied the role of the transcription factor, C/EBPβ, in the …

Chronic ethanol consumption disrupts whole-body lipid metabolism. Here we tested the
hypothesis that regulation of triglyceride homeostasis in adipose tissue is vulnerable to long-…

Determining how the regulation of cellular processes is impacted in cystic fibrosis (CF) is
fundamental to understanding disease pathology and to identifying new therapeutic targets. In …

We previously reported that 2 H 2 O can be used to measure rates of protein synthesis during
prolonged steady-state conditions (Previs SF, Fatica R, Chandramouli V, Alexander JC, …

The obesity epidemic has generated interest in determining the contribution of various
pathways to triglyceride synthesis, including an elucidation of the origin of triglyceride fatty acids …

Pancreatic β-cells are prone to endoplasmic reticulum (ER) stress due to their role in insulin
secretion. They require sustainable and efficient adaptive stress responses to cope with this …