Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder.
Mutations in presenilins 1 and 2 (PS1 and PS2) account for ∼40% of familial AD (FAD) cases. …

Neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD),
amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and spinocerebellar ataxias (…

Two classes of intracellular Ca 2+ -release channels, the ryanodine reccptor and the mositol
(1,4,5)-trisphosphate (IP 3 ) receptor, are essential for spatiotemporal Ca 2+ signalling in …

Perturbed neuronal Ca 2+ homeostasis is implicated in age-related cognitive impairment
and Alzheimer's disease (AD). With advancing age, neurons encounter increased oxidative …

Huntington's disease (HD) is caused by polyglutamine expansion (exp) in huntingtin (Htt). The
type 1 inositol (1,4,5)-triphosphate receptor (InsP 3 R1) is an intracellular calcium (Ca 2+ ) …

Huntington's disease (HD) is caused by polyglutamine expansion (exp) in huntingtin. Here,
we used a yeast artificial chromosome (YAC) transgenic mouse model of HD to investigate …

Alzheimer disease (AD) is the most common neurodegenerative disorder worldwide and is
at present, incurable. The accumulation of toxic amyloid-beta (Aβ) peptide aggregates in AD …

Presynaptic voltage-gated calcium (Ca 2+ ) channels mediate Ca 2+ influx into the presynaptic
terminal that triggers synaptic vesicle fusion and neurotransmitter release. The immediate …

▪ Abstract The precise regulation of neural excitability is essential for proper nerve cell, neural
circuit, and nervous system function. During postembryonic development and throughout …

Reelin, a large protein that regulates neuronal migration during embryonic development,
activates a conserved signaling pathway that requires its receptors, very low-density lipoprotein …