Pulmonary CCL18 recruits human regulatory T cells

C Chenivesse, Y Chang, I Azzaoui… - The Journal of …, 2012 - journals.aai.org
CCL18 is both a constitutively expressed and an inducible chemokine, whose role in the
inflammatory reaction is poorly known. The aim of this study was to evaluate whether CCL18 …

[HTML][HTML] High-affinity autoreactive plasma cells disseminate through multiple organs in patients with immune thrombocytopenic purpura

…, A Sokal, G Chenon, I Azzaoui… - The Journal of …, 2022 - Am Soc Clin Investig
The major therapeutic goal for immune thrombocytopenic purpura (ITP) is to restore normal
platelet counts using drugs to promote platelet production or by interfering with mechanisms …

[PDF][PDF] Maturation and persistence of the anti-SARS-CoV-2 memory B cell response

…, G Barba-Spaeth, A Roeser, S Fourati, I Azzaoui… - Cell, 2021 - cell.com
Memory B cells play a fundamental role in host defenses against viruses, but to date, their
role has been relatively unsettled in the context of SARS-CoV-2. We report here a longitudinal …

[PDF][PDF] mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants

…, G Barba-Spaeth, I Fernández, M Broketa, I Azzaoui… - Immunity, 2021 - cell.com
In addition to serum immunoglobulins, memory B cell (MBC) generation against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is another layer of immune protection, …

Early expansion of circulating granulocytic myeloid-derived suppressor cells predicts development of nosocomial infections in patients with sepsis

F Uhel, I Azzaoui, M Grégoire, C Pangault… - American journal of …, 2017 - atsjournals.org
Rationale: Sepsis induces a sustained immune dysfunction responsible for poor outcome
and nosocomial infections. Myeloid-derived suppressor cells (MDSCs) described in cancer …

T-cell defect in diffuse large B-cell lymphomas involves expansion of myeloid-derived suppressor cells

I Azzaoui, F Uhel, D Rossille, C Pangault… - Blood, The Journal …, 2016 - ashpublications.org
In diffuse large B-cell lymphoma (DLBCL), the number of circulating monocytes and neutrophils
represents an independent prognostic factor. These cell subsets include monocytic and …

Analysis of mRNA vaccination-elicited RBD-specific memory B cells reveals strong but incomplete immune escape of the SARS-CoV-2 Omicron variant

…, A Meola, I Fernández, S Fourati, I Azzaoui… - Immunity, 2022 - cell.com
The SARS-CoV-2 Omicron variant can escape neutralization by vaccine-elicited and
convalescent antibodies. Memory B cells (MBCs) represent another layer of protection against …

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

…, I Meyts, A Gervais, M Bouvier-Alias, I Azzaoui… - Journal of Experimental …, 2022 - rupress.org
Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening
COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination …

Rituximab-resistant splenic memory B cells and newly engaged naive B cells fuel relapses in patients with immune thrombocytopenia

…, P Chappert, A Sokal, S Weller, I Azzaoui… - Science translational …, 2021 - science.org
Rituximab (RTX), an antibody targeting CD20, is widely used as a first-line therapeutic strategy
in B cell–mediated autoimmune diseases. However, a large proportion of patients either …

SARS-CoV-2 Omicron BA. 1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals

…, I Fernández, M Broketa, A Meola, S Fourati, I Azzaoui… - Immunity, 2023 - cell.com
How infection by a viral variant showing antigenic drift impacts a preformed mature human
memory B cell (MBC) repertoire remains an open question. Here, we studied the MBC …