Patients with mutations of the recombination-activating genes (RAG) present with diverse
clinical phenotypes, including severe combined immune deficiency (SCID), autoimmunity, and …

Autoantibodies against cytokines, chemokines, and growth factors inhibit normal immunity
and are implicated in inflammatory autoimmune disease and diseases of immune deficiency. …

Objective Autoantibodies recognizing 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR)
are associated with statin exposure, the HLA allele DRB1*11:01, and necrotizing …

A hallmark of SLE is the production of high-titer, high-affinity, isotype-switched IgG autoantibodies
directed against nucleic acid–associated antigens. Several studies have established a …

Background Activation of Toll-like receptors (TLRs) induces inflammatory responses involved
in immunity to pathogens and autoimmune pathogenesis, such as in patients with systemic …

Several proteomics platforms have emerged in the past decade that show great promise for
filling in the many gaps that remain from earlier studies of the genome and from the …

Introduction Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized
by the production of high-titer IgG autoantibodies directed against nuclear autoantigens…

Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease with heightened
disease severity in children. The incomplete understanding of the precise cellular and …

Introduction Pediatric systemic lupus erythematosus (pSLE) patients often initially present
with more active and severe disease than adults, including a higher frequency of lupus …

High titer, class-switched autoantibodies are a hallmark of systemic lupus erythematosus (SLE).
Dysregulation of the interferon (IFN) pathway is observed in individuals with active SLE, …