Advances in single-cell technologies have enabled high-resolution dissection of tissue
composition. Several tools for dimensionality reduction are available to analyze the large number …

Neutrophils are specialized innate cells that require constant replenishment from proliferative
bone marrow (BM) precursors as a result of their short half-life. Although it is established …

Classically considered short-lived and purely defensive leukocytes, neutrophils are unique
in their fast and moldable response to stimulation. This plastic behavior may underlie …

Most tissue-resident macrophage (RTM) populations are seeded by waves of embryonic
hematopoiesis and are self-maintained independently of a bone marrow contribution during …

Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally
diverse; however, the extent and determinants of neutrophil heterogeneity in humans remain …

Granulocyte-monocyte progenitors (GMPs) have been previously defined for their potential
to generate various myeloid progenies such as neutrophils and monocytes. Although studies …

Myeloid cells are a significant proportion of leukocytes within tissues, comprising granulocytes,
monocytes, dendritic cells, and macrophages. With the identification of various myeloid …

The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe
complications are observed only in a small proportion of infected patients but the cellular …

Conventional dendritic cells (cDCs) are professional antigen-presenting cells that control
the adaptive immune response. Their subsets and developmental origins have been …