Precision oncology seeks to leverage molecular information about cancer to improve patient
outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited …

Markov state models provide a framework for understanding the fundamental states and
rates in the conformational dynamics of biomolecules. We describe an improved protocol for …

Purpose: Recent developments in genomics have led to expanded carrier screening panels
capable of assessing hundreds of causal mutations for genetic disease. This new …

Importance Screening for carrier status of a limited number of single-gene conditions is the
current standard of prenatal care. Methods have become available allowing rapid expanded …

Background Blood-based methods using cell-free DNA (cfDNA) are under development as
an alternative to existing screening tests. However, early-stage detection of cancer using …

Graphics processing units (GPUs) are gaining widespread use in high-performance computing
because of their performance advantages relative to CPUs. However, the reliability of …

Professional guidelines dictate that disease severity is a key criterion for carrier screening.
Expanded carrier screening, which tests for hundreds to thousands of mutations …

To identify potential therapeutic stop-gaps for SARS-CoV-2, we evaluated a library of 1,670
approved and reference compounds in an unbiased, cellular image-based screen for their …

Carrier screening is the practice of testing individuals to identify those at increased risks of
having children affected by genetic diseases. Professional guidelines on carrier screening …

Expanded carrier screening (ECS) analyzes dozens or hundreds of recessive genes to
determine reproductive risk. Data on the clinical utility of screening conditions beyond …