Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-arginine
to L-ornithine and urea. The action of arginase goes beyond the boundaries of hepatic …

Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein-1 (PD-1)/programmed
cell death ligand-1 (PD-L1) frequently induces tumor response in metastatic …

18 F-BMS-986192, an adnectin-based human programmed cell death ligand 1 (PD-L1)
tracer, was developed to noninvasively determine whole-body PD-L1 expression by PET. We …

Recently, N-(4- 18 F-fluorobenzoyl)-interleukin-2 ( 18 F-FB-IL2) was introduced as a PET
tracer for T cell imaging. However, production is complex and time-consuming. Therefore, we …

A series of indazoles substituted at the N-1 and N-2 positions with ester- containing side
chains -(CH 2 ) n CO 2 R of different lengths (n = 0-6, 9, 10) are described. Nucleophilic …

Background Molecular imaging of immune cells might be a potential tool for response prediction,
treatment evaluation and patient selection in inflammatory diseases as well as oncology…

Parathyroid diseases are characterized by dysregulation of calcium homeostasis and
alterations in parathyroid hormone (PTH) excretion. The development of parathyroid-targeted …

Statins are 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors that are widely
used to prevent cardiovascular diseases. However, a series of pleiotropic mechanisms have …

To increase the therapeutic index of chemotherapeutic drugs, prodrugs have been investigated
as anticancer agents, as they may present fewer cytotoxic side effects than conventional …

Estrogen receptors (ERs) are targets for endocrine treatment of estrogen-dependent cancers.
The ER consists of 2 isoforms, ERα and ERβ, which have distinct biologic functions. …