User profiles for Ines Lucía Patop
Inés Lucia PatopHarvard Medical School Verified email at hms.harvard.edu Cited by 1488 |
Past, present, and future of circ RNA s
Exonic circular RNA s (circ RNA s) are covalently closed RNA molecules generated by a
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of them …
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of them …
circRNAs in cancer
Exonic circular RNAs (circRNAs) are mostly generated from exons of protein-coding genes
and, in many cases, are more abundant that the linear product from their hosting gene. …
and, in many cases, are more abundant that the linear product from their hosting gene. …
Yeast GPCR signaling reflects the fraction of occupied receptors, not the number
…, A Constantinou, P Dunayevich, IL Patop… - Molecular systems …, 2016 - embopress.org
According to receptor theory, the effect of a ligand depends on the amount of agonist–receptor
complex. Therefore, changes in receptor abundance should have quantitative effects. …
complex. Therefore, changes in receptor abundance should have quantitative effects. …
[PDF][PDF] circMbl functions in cis and in trans to regulate gene expression and physiology in a tissue-specific fashion
Muscleblind (mbl) is an essential muscle and neuronal splicing regulator. Mbl hosts multiple
circular RNAs (circRNAs), including circMbl, which is conserved from flies to humans. Here, …
circular RNAs (circRNAs), including circMbl, which is conserved from flies to humans. Here, …
Thermosensitive alternative splicing senses and mediates temperature adaptation in Drosophila
A Martin Anduaga, N Evantal, IL Patop, O Bartok… - Elife, 2019 - elifesciences.org
Circadian rhythms are generated by the cyclic transcription, translation, and degradation of
clock gene products, including timeless (tim), but how the circadian clock senses and adapts …
clock gene products, including timeless (tim), but how the circadian clock senses and adapts …
[HTML][HTML] An in vivo strategy for knockdown of circular RNAs
Exonic circular RNAs (circRNAs) are highly abundant RNAs generated mostly from exons of
protein-coding genes. Assaying the functions of circRNAs is not straightforward as common …
protein-coding genes. Assaying the functions of circRNAs is not straightforward as common …
[HTML][HTML] SRCP: a comprehensive pipeline for accurate annotation and quantification of circRNAs
Here we describe a new integrative approach for accurate annotation and quantification of
circRNAs named Short Read circRNA Pipeline (SRCP). Our strategy involves two steps: …
circRNAs named Short Read circRNA Pipeline (SRCP). Our strategy involves two steps: …
An in vivo knockdown strategy reveals multiple functions for circMbl
…, O Bartok, S Wüst, K Seitz, R Maya, N Lerner, IL Patop… - bioRxiv, 2018 - biorxiv.org
Circular RNAs (circRNAs) are highly abundant and evolutionary conserved RNAs of mostly
unknown functions. circRNAs are enriched in the brain and accumulate with age in flies, …
unknown functions. circRNAs are enriched in the brain and accumulate with age in flies, …
In Vivo Tissue-Specific Knockdown of circRNAs Using shRNAs in Drosophila melanogaster
Studying circular RNAs’ function in vivo has been challenging due to the lack of generic
tools to manipulate their levels without affecting their linear counterparts. This is particularly …
tools to manipulate their levels without affecting their linear counterparts. This is particularly …
[PDF][PDF] An in vivo strategy for knockdown of circular RNAs
PN Reddy, IL Patop, K Aishwarya, AF Reut… - Cell …, 2020 - drive.google.com
Exonic circular RNAs (circRNAs) are highly abundant RNAs generated mostly from exons of
protein-coding genes. Assaying the functions of circRNAs is not straightforward as common …
protein-coding genes. Assaying the functions of circRNAs is not straightforward as common …