User profiles for Ines Lucía Patop

Inés Lucia Patop

Harvard Medical School
Verified email at hms.harvard.edu
Cited by 1488

Past, present, and future of circ RNA s

IL Patop, S Wüst, S Kadener - The EMBO journal, 2019 - embopress.org
Exonic circular RNA s (circ RNA s) are covalently closed RNA molecules generated by a
process named back‐splicing. circ RNA s are highly abundant in eukaryotes, and many of them …

circRNAs in cancer

IL Patop, S Kadener - Current opinion in genetics & development, 2018 - Elsevier
Exonic circular RNAs (circRNAs) are mostly generated from exons of protein-coding genes
and, in many cases, are more abundant that the linear product from their hosting gene. …

Yeast GPCR signaling reflects the fraction of occupied receptors, not the number

…, A Constantinou, P Dunayevich, IL Patop… - Molecular systems …, 2016 - embopress.org
According to receptor theory, the effect of a ligand depends on the amount of agonist–receptor
complex. Therefore, changes in receptor abundance should have quantitative effects. …

[PDF][PDF] circMbl functions in cis and in trans to regulate gene expression and physiology in a tissue-specific fashion

NR Pamudurti, IL Patop, A Krishnamoorthy, O Bartok… - Cell reports, 2022 - cell.com
Muscleblind (mbl) is an essential muscle and neuronal splicing regulator. Mbl hosts multiple
circular RNAs (circRNAs), including circMbl, which is conserved from flies to humans. Here, …

Thermosensitive alternative splicing senses and mediates temperature adaptation in Drosophila

A Martin Anduaga, N Evantal, IL Patop, O Bartok… - Elife, 2019 - elifesciences.org
Circadian rhythms are generated by the cyclic transcription, translation, and degradation of
clock gene products, including timeless (tim), but how the circadian clock senses and adapts …

[HTML][HTML] An in vivo strategy for knockdown of circular RNAs

NR Pamudurti, IL Patop, A Krishnamoorthy… - Cell discovery, 2020 - nature.com
Exonic circular RNAs (circRNAs) are highly abundant RNAs generated mostly from exons of
protein-coding genes. Assaying the functions of circRNAs is not straightforward as common …

[HTML][HTML] SRCP: a comprehensive pipeline for accurate annotation and quantification of circRNAs

A Rabin, M Zaffagni, R Ashwal-Fluss, IL Patop, A Jajoo… - Genome biology, 2021 - Springer
Here we describe a new integrative approach for accurate annotation and quantification of
circRNAs named Short Read circRNA Pipeline (SRCP). Our strategy involves two steps: …

An in vivo knockdown strategy reveals multiple functions for circMbl

…, O Bartok, S Wüst, K Seitz, R Maya, N Lerner, IL Patop… - bioRxiv, 2018 - biorxiv.org
Circular RNAs (circRNAs) are highly abundant and evolutionary conserved RNAs of mostly
unknown functions. circRNAs are enriched in the brain and accumulate with age in flies, …

In Vivo Tissue-Specific Knockdown of circRNAs Using shRNAs in Drosophila melanogaster

IL Patop, M Canori, S Kadener - Circular RNAs, 2024 - Springer
Studying circular RNAs’ function in vivo has been challenging due to the lack of generic
tools to manipulate their levels without affecting their linear counterparts. This is particularly …

[PDF][PDF] An in vivo strategy for knockdown of circular RNAs

PN Reddy, IL Patop, K Aishwarya, AF Reut… - Cell …, 2020 - drive.google.com
Exonic circular RNAs (circRNAs) are highly abundant RNAs generated mostly from exons of
protein-coding genes. Assaying the functions of circRNAs is not straightforward as common …