[HTML][HTML] SARS-CoV-2 escape in vitro from a highly neutralizing COVID-19 convalescent plasma

…, N Manganaro, A Manenti, R Manna, E Casa, I Hyseni… - BioRxiv, 2020 - ncbi.nlm.nih.gov
To investigate the evolution of SARS-CoV-2 in the immune population, we co-incubated
authentic virus with a highly neutralizing plasma from a COVID-19 convalescent patient. The …

[HTML][HTML] Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants

…, I Paciello, G Piccini, N Manganaro, P Pileri, I Hyseni… - Nature, 2021 - nature.com
The emergence of SARS-CoV-2 variants is jeopardizing the effectiveness of current vaccines
and limiting the application of monoclonal antibody-based therapy for COVID-19 (refs. ). …

SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma

…, R Manna, E Casa, I Hyseni… - Proceedings of the …, 2021 - National Acad Sciences
To investigate the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
in the immune population, we coincupi bated the authentic virus with a highly …

Unexpected detection of SARS-CoV-2 antibodies in the prepandemic period in Italy

…, A Manenti, M Boeri, F Sabia, I Hyseni… - Tumori …, 2021 - journals.sagepub.com
There are no robust data on the real onset of severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) infection and spread in the prepandemic period worldwide. We …

[HTML][HTML] Comparative analyses of SARS-CoV-2 binding (IgG, IgM, IgA) and neutralizing antibodies from human serum samples

L Mazzini, D Martinuzzi, I Hyseni, L Benincasa… - Journal of …, 2021 - Elsevier
A newly identified coronavirus, named SARS-CoV-2, emerged in December 2019 in Hubei
Province, China, and quickly spread throughout the world; so far, it has caused more than …

[HTML][HTML] Characterisation of SARS-CoV-2 lentiviral pseudotypes and correlation between pseudotype-based neutralisation assays and live virus-based micro …

I Hyseni, E Molesti, L Benincasa, P Piu, E Casa… - Viruses, 2020 - mdpi.com
The recent outbreak of a novel Coronavirus (SARS-CoV-2) and its rapid spread across the
continents has generated an urgent need for assays to detect the neutralising activity of …

[HTML][HTML] Safety and serum distribution of anti-SARS-CoV-2 monoclonal antibody MAD0004J08 after intramuscular injection

…, G Piccini, A Gentili, A Phogat, I Hyseni… - Nature …, 2022 - nature.com
The emerging threat represented by SARS-CoV-2 variants, demands the development of
therapies for better clinical management of COVID-19. MAD0004J08 is a potent Fc-engineered …

Cross-talk between endogenous H2S and NO accounts for vascular protective activity of the metal-nonoate Zn (PipNONO) Cl

M Monti, I Hyseni, A Pacini, E Monzani… - Biochemical …, 2018 - Elsevier
Nitric oxide (NO) and hydrogen sulfide (H 2 S) are now recognized as gaseous transmitters
with many cardiovascular protective properties. The present study concerns the possibility …

[HTML][HTML] Influenza anti-stalk antibodies: Development of a new method for the evaluation of the immune responses to universal vaccine

…, CM Trombetta, O Kistner, E Casa, I Hyseni… - Vaccines, 2020 - mdpi.com
Growing interest in universal influenza vaccines and novel administration routes has led to
the development of alternative serological assays that are able to detect antibodies against …

A single intramuscular injection of monoclonal antibody MAD0004J08 induces in healthy adults SARS-CoV-2 neutralising antibody titres exceeding those induced by …

…, I Paciello, G Piccini, A Gentili, A Phogat, I Hyseni… - MedRxiv, 2021 - medrxiv.org
Background The emerging threat represented by SARS-CoV-2 variants, demands the
development of therapies for better clinical management of COVID-19. MAD0004J08 is an …