The international neuroblastoma pathology classification (the Shimada system)

H Shimada, IM Ambros, LP Dehner… - … Journal of the …, 1999 - Wiley Online Library
BACKGROUND The International Neuroblastoma Pathology Committee, which is comprised
of six member pathologists, was convened with the objective of proposing a prognostically …

MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and …

IM Ambros, PF Ambros, S Strehl, H Kovar, H Gadner… - Cancer, 1991 - Wiley Online Library
This study reports on the specific expression of the MIC2 gene, a pseudoautosomal gene
located on the short arms of the X and Y chromosomes, on Ewing's sarcoma (ES) and …

Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee

H Shimada, IM Ambros, LP Dehner… - … Journal of the …, 1999 - Wiley Online Library
Ambros MD… The neuroblastic nodules are conceptually regarded as the consequence
of evolution of one or multiple aggressive or malignant clones, either because of newly …

[HTML][HTML] Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden

…, M Bernkopf, S Taschner-Mandl, IM Ambros… - Nature …, 2021 - nature.com
Sequencing of cell-free DNA in the blood of cancer patients (liquid biopsy) provides
attractive opportunities for early diagnosis, assessment of treatment response, and minimally …

Diagnostic and prognostic impact of urinary catecholamines in neuroblastoma patients

…, R Ladenstein, PF Ambros, IM Ambros… - Pediatric blood & …, 2007 - Wiley Online Library
Background Urinary catecholamine metabolites are well‐known to be elevated in patients
with neuroblastoma. Some investigators have described different patterns in favorable and …

Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumors: lack of INI1 in atypical teratoid/rhabdoid tumors and in a fraction of primitive …

…, I Slavc, T Czech, IM Ambros, PF Ambros… - The American journal …, 2006 - journals.lww.com
Immunohistochemical lack of nuclear INI1 protein expression has been recently described
as characteristic finding in atypical teratoid/rhabdoid tumors (AT/RTs), and has been …

[HTML][HTML] Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions

…, PF Ambros, IM Ambros, S Boral, M Lodrini… - Nature …, 2021 - nature.com
Intratumour heterogeneity is a major cause of treatment failure in cancer. We present in-depth
analyses combining transcriptomic and genomic profiling with ultra-deep targeted …

Vascular patterns in glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins: evidence for distinct angiogenic subtypes

…, C Marosi, PF Ambros, IM Ambros, M Bredel… - Brain …, 2003 - Wiley Online Library
No data exist on angiogenic patterns and their prognostic impact in human glioblastoma.
Such data are relevant for translation of antiangiogenic therapies into clinical applications. …

Genomic amplifications and distal 6q loss: novel markers for poor survival in high-risk neuroblastoma patients

…, R Cannoodt, IM Ambros, PF Ambros… - JNCI: Journal of the …, 2018 - academic.oup.com
Background Neuroblastoma is characterized by substantial clinical heterogeneity. Despite
intensive treatment, the survival rates of high-risk neuroblastoma patients are still …

Evaluation of deep learning architectures for complex immunofluorescence nuclear image segmentation

…, L Fischer, E Bozsaky, IM Ambros… - … on Medical Imaging, 2021 - ieeexplore.ieee.org
Separating and labeling each nuclear instance (instance-aware segmentation) is the key
challenge in nuclear image segmentation. Deep Convolutional Neural Networks have been …