Protein kinase C (PKC) is a ubiquitously expressed family of kinases that have key roles in
regulating multiple cellular activities. The activity of this family is controlled tightly by several …

Akt (also known as protein kinase B or PKB) comprises three closely related isoforms Akt1,
Akt2 and Akt3 (or PKBα/β/γ respectively). We have a very good understanding of the …

Integrin α IIb β 3 is a highly abundant heterodimeric platelet receptor that can transmit
information bidirectionally across the plasma membrane, and plays a critical role in hemostasis …

Background— Platelets are central to the process of hemostasis, rapidly aggregating at
sites of blood vessel injury and acting as coagulation nidus sites. On interaction with the …

Background Variation in adiposity is associated with cardiometabolic disease outcomes, but
mechanisms leading from this exposure to disease are unclear. This study aimed to …

Protein kinase B (Akt) plays a central role in cellular regulation, although many of the
physiologically relevant substrates for the kinase remain to be identified. In this study, we have …

Activation of platelets by collagen is mediated by the complex glycoprotein VI (GPVI)/Fc
receptor γ (FcRγ chain). In the current study, the role of 2 Src family kinases, Fyn and Lyn, in …

Glycogen synthase kinase-3 is a Ser/Thr kinase, tonically active in resting cells but inhibited
by phosphorylation of an N-terminal Ser residue (Ser 21 in GSK3α and Ser 9 in GSK3β) in …

Insulin-stimulated glucose uptake involves the recruitment of the glucose transporter 4 isoform
(GLUT4) from an intracellular location to the plasma membrane of fat and muscle cells. …

Here we report that the widely used protein kinase C inhibitors, bisindolylmaleimide I and IX,
are potent inhibitors of glycogen synthase kinase-3 (GSK-3). Bisindolylmaleimide I and IX …