Disassembly of the epithelial apical junctional complex (AJC), composed of the tight junction
(TJ) and adherens junction (AJ), is important for normal tissue remodeling and pathogen-…

Neutrophil (polymorphonuclear leukocytes [PMN]) transepithelial migration during inflammatory
episodes involves a complex series of adhesive interactions and signaling events. …

Phenol contamination of soil and water has raised concerns among people living near
phenol-producing factories and hazardous waste sites containing the chemical. Phenol, …

Junctional adhesion molecule-1 (JAM1) is a tight junction-associated immunoglobulin
superfamily protein implicated in the regulation of tight junctions and leukocyte transmigration. …

In experimental cultures, when bacteria are mixed with lytic (virulent) bacteriophage, bacterial
cells resistant to the phage commonly emerge and become the dominant population of …

In response to increasing frequencies of antibiotic-resistant pathogens, there has been a
resurrection of interest in the use of bacteriophage to treat bacterial infections: phage therapy. …

Background Epithelial tight junction (TJ) and adherens junction (AJ) form the apical junctional
complex (AJC) which regulates cell-cell adhesion, paracellular permeability and cell …

Most antibiotic use in humans is to reduce the magnitude and term of morbidity of acute,
community-acquired infections in immune competent patients, rather than to save lives. Thanks …

Nonreplicating bacteria are known to be (or at least commonly thought to be) refractory to
antibiotics to which they are genetically susceptible. Here, we explore the sensitivity to killing …

We postulate that the inhibition of growth and low rates of mortality of bacteria exposed to
ribosome-binding antibiotics deemed bacteriostatic can be attributed almost uniquely to these …