During angiogenesis, endothelial cells penetrate fibrin barriers via undefined proteolytic
mechanisms. We demonstrate that the fibrinolytic plasminogen activator (PA)-plasminogen …

The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin
remodelling 1 and is altered in over 20% of cancers 2 , 3 . Here we developed a proteolysis-…

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for
COVID-19, employs two key host proteins to gain entry and replicate within cells, angiotensin-…

Next-generation antiandrogen therapies, such as enzalutamide and abiraterone, have had
a profound impact on the management of metastatic castration-resistant prostate cancer (…

Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal
lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We …

Androgen receptor (AR) antagonists, such as enzalutamide, have had a major impact on the
treatment of metastatic castration-resistant prostate cancer (CRPC). However, even with the …

Transcription factors play a key role in the development of diverse cancers, and therapeutically
targeting them has remained a challenge. In prostate cancer, the gene encoding the …

We have studied the ability of c-myc and bcl-2 oncogenes to modulate p53 function. Our
studies show that coincident expression of human Bcl-2 protein with p53 prolongs survival of …

Selective degradation of the cyclin-dependent kinases 12 and 13 (CDK12/13) presents a
novel therapeutic opportunity for triple-negative breast cancer (TNBC), but there is still a lack of …

NRL, a bZIP transcription factor of the Maf subfamily, interacts with the homeodomain protein
CRX and synergistically regulates rhodopsin expression. Here we report that six isoforms …