The conserved Hippo kinase pathway plays a pivotal role in organ size control and tumor
suppression by restricting proliferation and promoting apoptosis. Whereas the function of the …

Drosophila neuroblasts 1 and ovarian stem cells 2 , 3 are well characterized models for stem
cell biology. In both cell types, one daughter cell self-renews continuously while the other …

The conserved Hippo signaling pathway acts in growth control and is fundamental to animal
development and oncogenesis [1–3]. Hippo signaling has also been implicated in adult …

The co-operation of specialized organ systems in complex multicellular organisms depends
on effective chemical communication. Thus, body fluids (like blood, lymph or intraspinal fluid…

Disruption of epithelial integrity contributes to chronic inflammatory disorders through
persistent activation of stress signalling. Here we uncover a mechanism whereby disruption of …

Background Insulin/insulin-like growth factor signalling (IIS) has been described as one of
the major pathways involved in growth control and homeostasis in multicellular organisms. …

CRISPR/Cas technology allows the creation of double strand breaks and hence loss of
function mutations at any location in the genome. This technology is now routine for many …

1 Summary Everything must grow and change to survive. Growth is an increase in biomass
over time, and the terminus can refer to mass increases of individual cells, tissues, organs or …

… We also acknowledge the advice and help of Ingrid Poernbacher, Kristina Stapornwongkul,
… We finally thank Barry Thompson, Ingrid Poernbacher, and Ian McGough for comments on …

… Gould and Ingrid Poernbacher for discussions. We also thank Pedro Gaspar for help generating
the reporters. Marvin Albert provided an early version of the Mercator projection routine. …