Intra-tumoral heterogeneity (ITH) could represent clonal evolution where subclones with
greater fitness confer more malignant phenotypes and invasion constitutes an evolutionary …

Brain tumor growth and tumor-induced edema result in increased intracranial pressure (ICP),
which, in turn, is responsible for conditions as benign as headaches and vomiting or as …

Glioblastomas are among the most lethal cancers, with a 5 year survival rate below 25%.
Temozolomide is typically used in glioblastoma treatment; however, the enzymes alkylpurine-…

Simple Summary Studying rare outcomes in cancer is challenging because observation of
the rare event may require a very high number of patients or experimental animals. Here, we …

The use of prostate‐specific antigen (PSA) as a prognostic indicator for prostate cancer (PCa)
patients is controversial, especially since it has been shown to correlate poorly with tumor …

Ductal carcinoma in situ (DCIS) and invasive breast cancer share many morphologic, proteomic,
and genomic alterations. Yet in contrast to invasive cancer, many DCIS tumors do not …

Introduction. Ductal carcinoma in situ (DCIS) of the breast has a limited propensity to
progress to invasive breast cancer. However, due to a lack of markers that predict the risk of …

Introduction. The natural history of preinvasive breast cancer, or ductal carcinoma in situ (DCIS)
remains poorly understood. Overcoming this gap would allow risk-appropriate treatment …

The specific dynamics of the model determine structural identifiability, which is considered
to be an analytical property of the model independent of clinical data. In general, a lack of …

… Inmaculada Concepcion Sorribes Rodriguez defended this dissertation on May 30, 2019.
The members of the supervisory committee were: … Con todo mi corazón, vuestra Inma. …