User profiles for Insup Choi
Insup ChoiIcahn School of Medicine at Mount Sinai Verified email at mssm.edu Cited by 1140 |
[HTML][HTML] Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
Microglia maintain brain homeostasis by removing neuron-derived components such as myelin
and cell debris. The evidence linking microglia to neurodegenerative diseases is growing…
and cell debris. The evidence linking microglia to neurodegenerative diseases is growing…
Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence
Dysfunctional autophagy has been implicated in the pathogenesis of Alzheimer’s disease (AD).
Previous evidence suggested disruptions of multiple stages of the autophagy-lysosomal …
Previous evidence suggested disruptions of multiple stages of the autophagy-lysosomal …
Occurrence of new vertebral body fracture after percutaneous vertebroplasty in patients with osteoporosis
…, LV Centenera, BA Pfiefer, AG Pazianos, IS Choi - Radiology, 2003 - pubs.rsna.org
PURPOSE: To investigate the prevalence and findings of vertebral body compression fractures
adjacent to those previously treated with percutaneous vertebroplasty. MATERIALS AND …
adjacent to those previously treated with percutaneous vertebroplasty. MATERIALS AND …
[HTML][HTML] The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease
Genetic and genomic studies have advanced our knowledge of inherited Parkinson’s disease
(PD), however, the etiology and pathophysiology of idiopathic PD remain unclear. Herein, …
(PD), however, the etiology and pathophysiology of idiopathic PD remain unclear. Herein, …
[HTML][HTML] LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase
In response to brain injury, microglia rapidly extend processes that isolate lesion sites and
protect the brain from further injury. Here we report that microglia carrying a pathogenic …
protect the brain from further injury. Here we report that microglia carrying a pathogenic …
Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy
Autophagy clears protein aggregates, damaged cellular organelles, and pathogens through
the lysosome. Although autophagy is highly conserved across all cell types, its activity in …
the lysosome. Although autophagy is highly conserved across all cell types, its activity in …
PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR
PINK1 (PTEN induced putative kinase 1), a familial Parkinson's disease (PD)‐related gene,
is expressed in astrocytes, but little is known about its role in this cell type. Here, we found …
is expressed in astrocytes, but little is known about its role in this cell type. Here, we found …
The effect of embolization with N-butyl cyanoacrylate prior to surgical resection of cerebral arteriovenous malformations
JJ Jafar, AJ Davis, A Berenstein, IS Choi… - Journal of …, 1993 - thejns.org
✓ Endovascular therapy of cerebral arteriovenous malformations (AVM's) is an accepted
adjunct to surgical therapy. However, the literature has not characterized the benefits or the …
adjunct to surgical therapy. However, the literature has not characterized the benefits or the …
[HTML][HTML] PINK1 deficiency enhances inflammatory cytokine release from acutely prepared brain slices
Parkinson's disease (PD) is the second most common neurodegenerative motor disease
caused by degeneration of dopaminergic neurons in the substantia nigra. Because brain …
caused by degeneration of dopaminergic neurons in the substantia nigra. Because brain …
Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth
…, M Blanca Ramirez, K Purtell, I Choi… - Proceedings of the …, 2021 - National Acad Sciences
Autophagy is a catabolic pathway that provides self-nourishment and maintenance of
cellular homeostasis. Autophagy is a fundamental cell protection pathway through metabolic …
cellular homeostasis. Autophagy is a fundamental cell protection pathway through metabolic …