User profiles for Insup Choi

Insup Choi

Icahn School of Medicine at Mount Sinai
Verified email at mssm.edu
Cited by 1140

[HTML][HTML] Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

I Choi, Y Zhang, SP Seegobin, M Pruvost… - Nature …, 2020 - nature.com
Microglia maintain brain homeostasis by removing neuron-derived components such as myelin
and cell debris. The evidence linking microglia to neurodegenerative diseases is growing…

Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence

I Choi, M Wang, S Yoo, P Xu, SP Seegobin, X Li… - Nature cell …, 2023 - nature.com
Dysfunctional autophagy has been implicated in the pathogenesis of Alzheimer’s disease (AD).
Previous evidence suggested disruptions of multiple stages of the autophagy-lysosomal …

Occurrence of new vertebral body fracture after percutaneous vertebroplasty in patients with osteoporosis

…, LV Centenera, BA Pfiefer, AG Pazianos, IS Choi - Radiology, 2003 - pubs.rsna.org
PURPOSE: To investigate the prevalence and findings of vertebral body compression fractures
adjacent to those previously treated with percutaneous vertebroplasty. MATERIALS AND …

[HTML][HTML] The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease

…, WM Song, Q Shen, A McKenzie, I Choi… - Nature …, 2019 - nature.com
Genetic and genomic studies have advanced our knowledge of inherited Parkinson’s disease
(PD), however, the etiology and pathophysiology of idiopathic PD remain unclear. Herein, …

[HTML][HTML] LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase

I Choi, B Kim, JW Byun, SH Baik, YH Huh… - Nature …, 2015 - nature.com
In response to brain injury, microglia rapidly extend processes that isolate lesion sites and
protect the brain from further injury. Here we report that microglia carrying a pathogenic …

Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy

I Choi, GR Heaton, YK Lee, Z Yue - Science advances, 2022 - science.org
Autophagy clears protein aggregates, damaged cellular organelles, and pathogens through
the lysosome. Although autophagy is highly conserved across all cell types, its activity in …

PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR

I Choi, J Kim, HK Jeong, B Kim, I Jou, SM Park, L Chen… - Glia, 2013 - Wiley Online Library
PINK1 (PTEN induced putative kinase 1), a familial Parkinson's disease (PD)‐related gene,
is expressed in astrocytes, but little is known about its role in this cell type. Here, we found …

The effect of embolization with N-butyl cyanoacrylate prior to surgical resection of cerebral arteriovenous malformations

JJ Jafar, AJ Davis, A Berenstein, IS Choi… - Journal of …, 1993 - thejns.org
✓ Endovascular therapy of cerebral arteriovenous malformations (AVM's) is an accepted
adjunct to surgical therapy. However, the literature has not characterized the benefits or the …

[HTML][HTML] PINK1 deficiency enhances inflammatory cytokine release from acutely prepared brain slices

J Kim, JW Byun, I Choi, B Kim, HK Jeong… - Experimental …, 2013 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is the second most common neurodegenerative motor disease
caused by degeneration of dopaminergic neurons in the substantia nigra. Because brain …

Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth

…, M Blanca Ramirez, K Purtell, I Choi… - Proceedings of the …, 2021 - National Acad Sciences
Autophagy is a catabolic pathway that provides self-nourishment and maintenance of
cellular homeostasis. Autophagy is a fundamental cell protection pathway through metabolic …