User profiles for Iona M. MacLeod
Iona MacleodSenior Research Scientist, Agriculture Victoria Research, Department of Economic … Verified email at agriculture.vic.gov.au Cited by 2858 |
[HTML][HTML] Genome-wide fine-mapping identifies pleiotropic and functional variants that predict many traits across global cattle populations
The difficulty in finding causative mutations has hampered their use in genomic prediction.
Here, we present a methodology to fine-map potentially causal variants genome-wide by …
Here, we present a methodology to fine-map potentially causal variants genome-wide by …
Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits
Many genome variants shaping mammalian phenotype are hypothesized to regulate gene
transcription and/or to be under selection. However, most of the evidence to support this …
transcription and/or to be under selection. However, most of the evidence to support this …
[HTML][HTML] Evaluation of the accuracy of imputed sequence variant genotypes and their utility for causal variant detection in cattle
Background The availability of dense genotypes and whole-genome sequence variants
from various sources offers the opportunity to compile large datasets consisting of tens of …
from various sources offers the opportunity to compile large datasets consisting of tens of …
Inferring demography from runs of homozygosity in whole-genome sequence, with correction for sequence errors
Whole-genome sequence is potentially the richest source of genetic data for inferring ancestral
demography. However, full sequence also presents significant challenges to fully utilize …
demography. However, full sequence also presents significant challenges to fully utilize …
[HTML][HTML] New loci and neuronal pathways for resilience to heat stress in cattle
While understanding the genetic basis of heat tolerance is crucial in the context of global
warming’s effect on humans, livestock, and wildlife, the specific genetic variants and biological …
warming’s effect on humans, livestock, and wildlife, the specific genetic variants and biological …
Whole-genome resequencing of two elite sires for the detection of haplotypes under selection in dairy cattle
…, J Thimmapuram, IM Macleod… - Proceedings of the …, 2012 - National Acad Sciences
Using a combination of whole-genome resequencing and high-density genotyping arrays,
genome-wide haplotypes were reconstructed for two of the most important bulls in the history …
genome-wide haplotypes were reconstructed for two of the most important bulls in the history …
[HTML][HTML] Population structure and history of the Welsh sheep breeds determined by whole genome genotyping
…, B Davies, W Haresign, J Kijas, IM MacLeod… - BMC genetics, 2015 - Springer
Background One of the most economically important areas within the Welsh agricultural
sector is sheep farming, contributing around £230 million to the UK economy annually. …
sector is sheep farming, contributing around £230 million to the UK economy annually. …
[HTML][HTML] Genomic prediction based on selected variants from imputed whole-genome sequence data in Australian sheep populations
Background Whole-genome sequence (WGS) data could contain information on genetic
variants at or in high linkage disequilibrium with causative mutations that underlie the genetic …
variants at or in high linkage disequilibrium with causative mutations that underlie the genetic …
The effects of demography and long-term selection on the accuracy of genomic prediction with sequence data
The use of dense SNPs to predict the genetic value of an individual for a complex trait is
often referred to as “genomic selection” in livestock and crops, but is also relevant to human …
often referred to as “genomic selection” in livestock and crops, but is also relevant to human …
[HTML][HTML] In it for the long run: perspectives on exploiting long-read sequencing in livestock for population scale studies of structural variants
Studies have demonstrated that structural variants (SV) play a substantial role in the evolution
of species and have an impact on Mendelian traits in the genome. However, unlike small …
of species and have an impact on Mendelian traits in the genome. However, unlike small …