The difficulty in finding causative mutations has hampered their use in genomic prediction.
Here, we present a methodology to fine-map potentially causal variants genome-wide by …

Many genome variants shaping mammalian phenotype are hypothesized to regulate gene
transcription and/or to be under selection. However, most of the evidence to support this …

Background The availability of dense genotypes and whole-genome sequence variants
from various sources offers the opportunity to compile large datasets consisting of tens of …

Whole-genome sequence is potentially the richest source of genetic data for inferring ancestral
demography. However, full sequence also presents significant challenges to fully utilize …

While understanding the genetic basis of heat tolerance is crucial in the context of global
warming’s effect on humans, livestock, and wildlife, the specific genetic variants and biological …

Using a combination of whole-genome resequencing and high-density genotyping arrays,
genome-wide haplotypes were reconstructed for two of the most important bulls in the history …

Background One of the most economically important areas within the Welsh agricultural
sector is sheep farming, contributing around £230 million to the UK economy annually. …

Background Whole-genome sequence (WGS) data could contain information on genetic
variants at or in high linkage disequilibrium with causative mutations that underlie the genetic …

The use of dense SNPs to predict the genetic value of an individual for a complex trait is
often referred to as “genomic selection” in livestock and crops, but is also relevant to human …

Studies have demonstrated that structural variants (SV) play a substantial role in the evolution
of species and have an impact on Mendelian traits in the genome. However, unlike small …