AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity
…, C Pehmøller, N Sanz, I Sakakibara… - The FASEB …, 2014 - Wiley Online Library
AMP‐activated protein kinase (AMPK) is a sensor of cellular energy status that plays a central
role in skeletal muscle metabolism. We used skeletal muscle‐specific AMPKα1α2 double‐…
role in skeletal muscle metabolism. We used skeletal muscle‐specific AMPKα1α2 double‐…
The peroxisome proliferator-activated receptor γ/retinoid X receptor α heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates …
…, NS Nishikawa, T Tanaka, I Sakakibara… - … and cellular biology, 2009 - Taylor & Francis
Control of cell differentiation occurs through transcriptional mechanisms and through epigenetic
modification. Using a chromatin immunoprecipitation-on-chip approach, we performed a …
modification. Using a chromatin immunoprecipitation-on-chip approach, we performed a …
COUP-TFII acts downstream of Wnt/β-catenin signal to silence PPARγ gene expression and repress adipogenesis
…, A Uchida, S Tsutsumi, I Sakakibara… - Proceedings of the …, 2009 - National Acad Sciences
Wnt signaling through β-catenin and TCF maintains preadipocytes in an un-differentiated
proliferative state; however, the molecular pathway has not been completely defined. By …
proliferative state; however, the molecular pathway has not been completely defined. By …
A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice
…, YI Kawasawa, Y Ikeda, I Sakakibara… - Proceedings of the …, 2006 - National Acad Sciences
Here, we report the isolation and characterization of an endogenous peptide ligand of GPR103
from rat brains. The purified peptide was found to be the 43-residue RF-amide peptide …
from rat brains. The purified peptide was found to be the 43-residue RF-amide peptide …
[HTML][HTML] Polyphenols and their effects on muscle atrophy and muscle health
T Nikawa, A Ulla, I Sakakibara - Molecules, 2021 - mdpi.com
Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced
protein synthesis/accelerated protein degradation. Various conditions, such as denervation, …
protein synthesis/accelerated protein degradation. Various conditions, such as denervation, …
[HTML][HTML] Analysis of DNA Repair and Protection in the Tardigrade Ramazzottius varieornatus and Hypsibius dujardini after Exposure to UVC Radiation
DD Horikawa, J Cumbers, I Sakakibara, D Rogoff… - PloS one, 2013 - journals.plos.org
Tardigrades inhabiting terrestrial environments exhibit extraordinary resistance to ionizing
radiation and UV radiation although little is known about the mechanisms underlying the …
radiation and UV radiation although little is known about the mechanisms underlying the …
[PDF][PDF] Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2
I Sakakibara, T Fujino, M Ishii, T Tanaka, T Shimosawa… - Cell metabolism, 2009 - cell.com
Acetate is activated to acetyl-CoA by acetyl-CoA synthetase 2 (AceCS2), a mitochondrial
enzyme. Here, we report that the activation of acetate by AceCS2 has a specific and unique …
enzyme. Here, we report that the activation of acetate by AceCS2 has a specific and unique …
Cooperative Interaction between Hepatocyte Nuclear Factor 4α and GATA Transcription Factors Regulates ATP-Binding Cassette Sterol Transporters ABCG5 and …
…, T Maejima, N Kojima, I Sakakibara… - … and cellular biology, 2007 - Taylor & Francis
Cholesterol homeostasis is maintained by coordinate regulation of cholesterol synthesis and
its conversion to bile acids in the liver. The excretion of cholesterol from liver and intestine …
its conversion to bile acids in the liver. The excretion of cholesterol from liver and intestine …
[HTML][HTML] A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes
…, D Noordermeer, F Relaix, I Sakakibara… - Nature …, 2022 - nature.com
The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform
content. Here, we identify by snATAC-seq a 42 kb super-enhancer at the locus regrouping …
content. Here, we identify by snATAC-seq a 42 kb super-enhancer at the locus regrouping …
[HTML][HTML] Six homeoproteins and a linc-RNA at the fast MYH locus lock fast myofiber terminal phenotype
Thousands of long intergenic non-coding RNAs (lincRNAs) are encoded by the mammalian
genome. However, the function of most of these lincRNAs has not been identified in vivo. …
genome. However, the function of most of these lincRNAs has not been identified in vivo. …