Renin-angiotensin systems may mediate cardiovascular disease pathogenesis through a
balance of actions of angiotensin II on (potentially proatherogenic) constitutive type 1 (AT 1 R) …

In ST-segment elevation myocardial infarction of both patients and mice, there was a
decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. …

Aims The contribution of kinins to the beneficial effects of angiotensin I converting enzyme (ACE)
inhibition in cardiovascular risk reduction remains unclear. The genes for the kinin …

INTRODUCTION: Several inflammatory markers have been shown to be independent
predictors for both the development of clinically significant atherosclerosis and for adverse …

Background Cardiopulmonary bypass during cardiac surgery can result in a shortfall in oxygen
delivery relative to demand, marked by a decrease in muscle tissue oxygen saturation as …

Background Extracellular microRNAs enter kidney cells and modify gene expression. We
used a Dicer-hepatocyte-specific microRNA conditional-knock-out (Dicer-CKO) mouse to …

Activation of the innate immune response following myocardial infarction (MI) is essential for
infarct repair. Preclinical models of MI commonly use C57BL/6 mice, which have a type 1-…

BACKGROUND: The neutrophil count has been associated with adverse cardiovascular
events after percutaneous coronary intervention. There are limited data on risk stratification of …

BACKGROUND: Anemia is a risk factor for adverse outcome in patients with symptomatic
cardiovascular disease. This study assessed the association of preprocedural hemoglobin with …

Several inflammatory diseases including multiple sclerosis and inflammatory bowel disease
have been associated with dysfunctional and/or reduced numbers of Foxp3 + regulatory T …