Diabetic nephropathy (DN) is the leading cause of kidney failure, with an increasing incidence
worldwide. Mitochondrial dysfunction is known to occur in DN and has been implicated in …

Hyperglycemia is well‐recognized and has long‐term complications in diabetes mellitus
and diabetic nephropathy. In podocytes, the main component of the glomerular barrier, …

Podocyte insulin sensitivity is critical for glomerular function, and the loss of appropriate
insulin signaling leads to alterations and disorders featuring diabetic nephropathy. Energy-…

Podocytes constitute the outer layer of the renal glomerular filtration barrier. Their energy
requirements strongly depend on efficient oxidative respiration, which is tightly connected with …

As part of the filtration barrier, podocytes play an important role in the development of diabetic
nephropathy. Disturbances in insulin signaling accompanied by insulin resistance can …

Hyperglycemic conditions (HG), at early stages of diabetic nephropathy (DN), cause a
decrease in podocyte numbers and an aberration of their function as key cells for glomerular …

Podocytes have foot processes that comprise an important cellular layer of the glomerular
barrier involved in regulating glomerular permeability. The disturbance of podocyte function …

Podocytes are unique, highly specialized, terminally differentiated cells that form an essential,
integral part of the glomerular filter. These cells limit the outside border of the glomerular …

Background/Aims: Podocytes are dynamic polarized cells on the surface of glomerular
capillaries that are an essential part of the glomerular filtration barrier. AMP-activated protein …

Growing evidence indicates that in diabetes, high glucose concentrations affect podocyte
metabolism and function. The crucial pathological feature of type 2 diabetes mellitus and …