Enhanced detection of circulating tumor DNA by fragment size analysis
Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on
genomic alterations but have rarely considered the biological properties of plasma cell-free …
genomic alterations but have rarely considered the biological properties of plasma cell-free …
CXCR4 inhibition in human pancreatic and colorectal cancers induces an integrated immune response
…, FA Gallagher, M Pawula, I Hudecova… - Proceedings of the …, 2020 - National Acad Sciences
Inhibition of the chemokine receptor CXCR4 in combination with blockade of the PD-1/PD-L1
T cell checkpoint induces T cell infiltration and anticancer responses in murine and human …
T cell checkpoint induces T cell infiltration and anticancer responses in murine and human …
ctDNA monitoring using patient-specific sequencing and integration of variant reads
…, E Barker, G Young, WN Cooper, I Hudecova… - Science translational …, 2020 - science.org
Circulating tumor-derived DNA (ctDNA) can be used to monitor cancer dynamics noninvasively.
Detection of ctDNA can be challenging in patients with low-volume or residual disease, …
Detection of ctDNA can be challenging in patients with low-volume or residual disease, …
Digital PCR analysis of circulating nucleic acids
I Hudecova - Clinical biochemistry, 2015 - Elsevier
Detection of plasma circulating nucleic acids (CNAs) requires the use of extremely sensitive
and precise methods. The commonly used quantitative real-time polymerase chain reaction (…
and precise methods. The commonly used quantitative real-time polymerase chain reaction (…
Second generation noninvasive fetal genome analysis reveals de novo mutations, single-base parental inheritance, and preferred DNA ends
…, SH Cheng, AIC Wong, I Hudecova… - Proceedings of the …, 2016 - National Acad Sciences
Plasma DNA obtained from a pregnant woman was sequenced to a depth of 270× haploid
genome coverage. Comparing the maternal plasma DNA sequencing data with the parental …
genome coverage. Comparing the maternal plasma DNA sequencing data with the parental …
Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients
…, J Hadfield, M Grzelak, I Hudecova… - EMBO molecular …, 2021 - embopress.org
Glioma‐derived cell‐free DNA (cfDNA) is challenging to detect using liquid biopsy because
quantities in body fluids are low. We determined the glioma‐derived DNA fraction in …
quantities in body fluids are low. We determined the glioma‐derived DNA fraction in …
[HTML][HTML] Maternal plasma fetal DNA fractions in pregnancies with low and high risks for fetal chromosomal aneuploidies
I Hudecova, D Sahota, MMS Heung, Y Jin, WS Lee… - PloS one, 2014 - journals.plos.org
Recently published international guidelines recommend the clinical use of noninvasive
prenatal test (NIPT) for aneuploidy screening only among pregnant women whose fetuses are …
prenatal test (NIPT) for aneuploidy screening only among pregnant women whose fetuses are …
Characteristics, origin, and potential for cancer diagnostics of ultrashort plasma cell-free DNA
I Hudecova, CG Smith, R Hänsel-Hertsch… - Genome …, 2022 - genome.cshlp.org
Current evidence suggests that plasma cell-free DNA (cfDNA) is fragmented around a mode
of 166 bp. Data supporting this view has been mainly acquired through the analysis of …
of 166 bp. Data supporting this view has been mainly acquired through the analysis of …
[HTML][HTML] Comprehensive characterization of cell-free tumor DNA in plasma and urine of patients with renal tumors
Background Cell-free tumor-derived DNA (ctDNA) allows non-invasive monitoring of
cancers, but its utility in renal cell cancer (RCC) has not been established. Methods Here, a …
cancers, but its utility in renal cell cancer (RCC) has not been established. Methods Here, a …
Noninvasive detection of F8 int22h-related inversions and sequence variants in maternal plasma of hemophilia carriers
I Hudecova, P Jiang, J Davies, YMD Lo… - Blood, The Journal …, 2017 - ashpublications.org
Direct detection of F8 and F9 sequence variants in maternal plasma of hemophilia carriers
has been demonstrated by microfluidics digital PCR. Noninvasive prenatal assessment of the …
has been demonstrated by microfluidics digital PCR. Noninvasive prenatal assessment of the …