Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial
Parkinson's disease. We found LRRK2 to be degraded in lysosomes by chaperone-mediated …

Parkinson's disease (PD) is associated with the degeneration of ventral midbrain
dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell-autonomous …

Parkinson’s disease (PD) is a common neurodegenerative disease that lacks therapies to
prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels …

A deeper understanding of early disease mechanisms occurring in Parkinson’s disease (PD)
is needed to reveal restorative targets. Here we report that human induced pluripotent stem …

Accumulation of misfolded α-synuclein (α-syn) is a hallmark of Parkinson’s disease (PD)
thought to play important roles in the pathophysiology of the disease. Dendritic systems, able to …

Parkinson’s disease is associated with intracellular α-synuclein accumulation and ventral
midbrain dopaminergic neuronal death in the Substantia Nigra of brain patients. The Rho …

Patient-specific induced pluripotent stem cells (iPSCs) are a powerful tool to investigate the
molecular mechanisms underlying Parkinson’s disease (PD), and might provide novel …

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Proteostatic regulation of tyrosine hydroxylase (TH), the rate‐limiting enzyme in dopamine
biosynthesis, is crucial for maintaining proper brain neurotransmitter homeostasis. Variants of …

Tyrosine hydroxylase deficiency (THD) is a rare genetic disorder leading to dopaminergic
depletion and early‐onset Parkinsonism. Affected children present with either a severe form …