We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old
hunter-gatherers from Luxembourg and Sweden. We analysed these and other …

Genome-sequencing studies indicate that all humans carry many genetic variants predicted
to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy …

The hypothesis that differences in gene regulation have an important role in speciation and
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …

The self-renewal and differentiation capacities of human pluripotent stem cells (hPSCs)
make them a promising source of material for cell transplantation therapy, drug development, …

We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock
of hair donated by an Aboriginal man from southern Western Australia in the early 20th …

Background The use of low quality RNA samples in whole-genome gene expression profiling
remains controversial. It is unclear if transcript degradation in low quality RNA samples …

Here we report the Simons Genome Diversity Project data set: high quality genomes from 300
individuals from 142 diverse populations. These genomes include at least 5.8 million base …

INTRODUCTION Most studies of human genetic variation have focused on single-nucleotide
variants (SNVs). However, copy-number variants (CNVs) affect more base pairs of DNA …

Humans and their ancestors have traversed the Ethiopian landscape for millions of years,
and present-day Ethiopians show great cultural, linguistic, and historical diversity, which …

South Asia harbors one of the highest levels genetic diversity in Eurasia, which could be
interpreted as a result of its long-term large effective population size and of admixture during its …