Background and Aims Hepatic ischemia–reperfusion injury (IRI) is the leading cause of
early posttransplantation organ failure as mitochondrial respiration and ATP production are …

Magnesium(II) plays catalytic, structural, regulatory, and signaling roles in living organisms.
Abnormal levels of this metal have been associated with numerous pathologies, including …

Acetaminophen overdose is one of the leading causes of acute liver failure and liver
transplantation in the Western world. Magnesium is essential in several cellular processess. The …

The cyclin and cystathionine β-synthase (CBS) domain magnesium transport mediators,
CNNMs, are key players in maintaining the homeostasis of magnesium in different organs. The …

Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg 2+ ) homeostasis.
Using various biochemical approaches, we have identified members of the CNNM family as …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a multi-organ
damage that includes hepatic dysfunction, which has been observed in over 50% of COVID-19 …

Background & Aims Perturbations of intracellular magnesium (Mg 2+ ) homeostasis have
implications for cell physiology. The cyclin M family, CNNM, perform key functions in the …

Within the organism, the liver is the main organ responsible for metabolic homeostasis and
xenobiotic transformation. In order to maintain an adequate liver weight-to-bodyweight ratio, …

The posttranslational modification of proteins critically influences many biological processes
and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R …

The four member family of “Cyclin and Cystathionine β-synthase (CBS) domain divalent
metal cation transport mediators”, CNNMs, are the least-studied mammalian magnesium …