Apoptosis is orchestrated by the concerted action of caspases, activated in a minimal two-step
proteolytic cascade. Existing data suggests that apical caspases are activated by adaptor-…

RNA interference through non-coding microRNAs (miRNAs) represents a vital component of
the innate antiviral immune response in plants and invertebrate animals; however, a role for …

Apoptosis resistance commonly occurs in cancers, preventing activation of Caspase family
cell death proteases. XIAP is an endogenous inhibitor of Caspases overexpressed in many …

We showed that Eμ-MiR-155 transgenic mice develop acute lymphoblastic leukemia/high-grade
lymphoma. Most of these leukemias start at approximately 9 months irrespective of the …

Antibodies against CD20 can activate complement and induce antibody-dependent cellular
cytotoxicity (ADCC) in B lymphocytes. In B-cell lines, such antibodies also induce apoptosis. …

Chronic lymphocytic leukemia (CLL) B cells have defects in apoptosis pathways and therefore
accumulate in vivo. However, when removed from the patient and cultured in vitro, these …

There is an increasing array of functional foods available that are designed to confer health
benefits. However, individuals’ worries about new technology and modernity may influence …

Non‐coding microRNAs (miRs) are a vital component of post‐transcriptional modulation of
protein expression and, like coding mRNAs harbour oncogenic properties. However, the …

Ever since the discovery of Bcl-2 and the elucidation of its role in apoptosis, tremendous
interest has arisen in prospects for triggering suicide of malignant cells by exploiting knowledge …

MicroRNAs (miRs) were only discovered little more than a decade ago, yet it has become
rapidly clear that they are crucial posttranscriptional regulators of gene expression by …