Human mesenchymal stem/progenitor cells (MSCs) have been identified in adult bone
marrow, but little is known about their presence during fetal life. MSCs were isolated and …

Definitive haematopoiesis in the fetal liver supports self-renewal and differentiation of
haematopoietic stem cells and multipotent progenitors (HSC/MPPs) but remains poorly defined in …

Background In alloimmune anemia of the newborn, the level of hemolysis caused by the
presence of antibodies to antigens of the Kell blood-group system is less than that caused by …

The upcoming 5th edition of the World Health Organization (WHO) Classification of
Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in …

Most patients with rare diseases do not receive a molecular diagnosis and the aetiological
variants and causative genes for more than half such disorders remain to be discovered 1 . …

The ontogeny of haemopoiesis during fetal life and the differentiation of blood cells in adult
life depend upon a fully competent microenvironment to provide appropriate signals via …

Fifty children who had symptomatic sickle cell disease received matched sibling marrow
allografts between September 1991 and March 1999, with Kaplan-Meier probabilities of survival …

Bone involvement is the commonest clinical manifestation of sickle cell disease both in the
acute setting such as painful vaso‐occlusive crises, and as a source of chronic, progressive …

Allogeneic bone marrow transplantation (BMT) from HLA-identical siblings is an accepted
treatment for both thalassemia and sickle cell disease (SCD). However, it is associated with …

… Brenda ES Gibson, Audrey Todd, Irene Roberts, Derwood Pamphilon, Charles Rodeck,
Paula Bolton-Maggs, Geoff Burbin, J Duguid, F Boulton, H Cohen, N Smith, DBL McClelland …