The recent advent of CRISPR and other molecular tools enabled the reconstruction of cell
lineages based on induced DNA mutations and promises to solve the ones of more complex …

Pelagic larval stages are widespread across animals, yet it is unclear whether larvae were
present in the last common ancestor of animals or whether they evolved multiple times due to …

10.7554/eLife.40292.001 Cell lineages provide the framework for understanding how cell
fates are decided during development. Describing cell lineages in most organisms is …

In some eukaryotes, a ‘hidden break’ has been described in which the 28S ribosomal RNA
molecule is cleaved into two subparts. The break is common in protostome animals (…

We present a survey of selection across Drosophila melanogaster embryonic anatomy. Our
approach integrates genomic variation, spatial gene expression patterns, and development …

Recent innovations in genetics and imaging are providing the means to reconstruct cell
lineages, either by tracking cell divisions using live microscopy, or by deducing the history of …

Previous studies of the evolution of genes expressed at different life-cycle stages of Drosophila
melanogaster have not been able to disentangle adaptive from nonadaptive substitutions …

The cellular complexity of the endochondral bone underlies its essential and pleiotropic roles
during organismal life. While the adult bone has received significant attention, we still lack …

One of the most apparent phenomena in development is that it starts with something apparently
simple and leads to something clearly complex with a specific and functional structure. …

The increase in complexity in an embryo over developmental time is perhaps one of the
most intuitive processes of animal development. It is also intuitive that the embryo becomes …