The clinical course of breast cancer varies from one patient to another. Currently, the choice
of therapy relies on clinical parameters and histological and molecular tumor features. Alas, …

Intratumor heterogeneity is a major challenge in cancer treatment. To decipher patterns of
chromosomal heterogeneity, we analyzed six colorectal cancer cell lines by multiplex …

Purpose: The standard treatment of patients with locally advanced rectal cancer consists of
preoperative chemoradiotherapy (CRT) followed by surgery. However, the response of …

Simple Summary The majority (69.7%) of women diagnosed with breast cancer are above
the age of 55. The population of older breast cancer patients is growing. Nevertheless, older …

Colorectal adenomas are common precancerous lesions with the potential for malignant
transformation to colorectal adenocarcinoma. Endoscopic polypectomy provides an opportunity …

Prognosis in young patients with breast cancer is generally poor, yet considerable differences
in clinical outcomes between individual patients exist. To understand the genetic basis of …

Despite decades of study of chromosome territories (CT) in the interphase nucleus of mammalian
cells, our understanding of the global shape and 3-D organization of the individual CT …

Tetraploidy, a common feature in cancer, results in the presence of extra centrosomes, which
has been associated with chromosome instability (CIN) and aneuploidy. Deregulation in …

Motivation Computational reconstruction of clonal evolution in cancers has become a crucial
tool for understanding how tumors initiate and progress and how this process varies across …

Nonalcoholic steatohepatitis (NASH)-induced hepatocellular carcinoma (HCC) and its precursor,
nonalcoholic fatty liver disease (NAFLD) are an unmet health issue due to widespread …