The oral microbiome plays key roles in human biology, health, and disease, but little is
known about the global diversity, variation, or evolution of this microbial community. To better …

Atherosclerotic vascular disease is a leading cause of myocardial infarction and cerebrovascular
accident, and independent associations with periodontal disease (PD) are reported. …

Archaeological dental calculus has emerged as a rich source of ancient biomolecules, including
proteins. Previous analyses of proteins extracted from ancient dental calculus revealed …

Background Dental calculus, calcified oral plaque biofilm, contains microbial and host
biomolecules that can be used to study historic microbiome communities and host responses. …

Major advances over the past decade in the field of ancient DNA are providing access to
past paleogenomic diversity, but the diverse functions and biosynthetic capabilities of this …

Periodontal disease (PD) and atherosclerosis are both polymicrobial and multifactorial and
although observational studies supported the association, the causative relationship …

Periodontal disease (PD) develops from a synergy of complex subgingival oral microbiome,
and is linked to systemic inflammatory atherosclerotic vascular disease (ASVD). To …

Treponema denticola is a predominantly subgingival oral spirochete closely associated with
periodontal disease and has been detected in atherosclerosis. This study was designed to …

Tannerella forsythia is a Gram-negative anaerobic organism that inhabits the subgingival
cavity and initiates connective tissue destruction and alveolar bone resorption in periodontal …

Introduction Dental calculus is a mineralized microbial dental plaque biofilm that forms
throughout life by precipitation of salivary calcium salts. Successive cycles of dental plaque …