INTRODUCTION Mammalian genes that play prominent roles in healthy and diseased cellular
states are often controlled by special DNA elements called super-enhancers (SEs). SEs …

Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but …

The nucleus contains diverse phase-separated condensates that compartmentalize and
concentrate biomolecules with distinct physicochemical properties. Here, we investigated …

In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …

Chromosomal rearrangements, including translocations, require formation and joining of
DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are …

Mammalian cells repair DNA double-strand breaks (DSBs) through either homologous
recombination or non-homologous end joining (NHEJ). V(D)J recombination, a cut-and-paste …

Malignant transformation is characterized by dysregulation of diverse cellular processes
that have been the subject of detailed genetic, biochemical, and structural studies, but only …

Enhancers are DNA elements that are bound by transcription factors (TFs), which recruit
coactivators and the transcriptional machinery to genes. Phase-separated condensates of TFs …

Cancer-initiating translocations such as those associated with lymphomas require the formation
of paired DNA double-strand breaks (DSBs). Activation-induced cytidine deaminase (AID…

53BP1 is a DNA damage protein that forms phosphorylated H2AX (γ-H2AX) dependent foci
in a 1 Mb region surrounding DNA double-strand breaks (DSBs). In addition, 53BP1 …