Background Increasing evidence indicates that redox stress participates in MFS aortopathy,
though its mechanistic contribution is little known. We reported elevated reactive oxygen …

Objective: We investigated the effect of a potent TGFβ (transforming growth factor β) inhibitor
peptide (P144) from the betaglycan/TGFβ receptor III on aortic aneurysm development in a …

Williams–Beuren syndrome (WBS) is a rare disorder caused by a recurrent microdeletion
with hallmarks of cardiovascular manifestations, mainly supra-valvular aortic stenosis (SVAS). …

Williams-Beuren syndrome (WBS) is a rare neurodevelopmental disorder with hallmarks in
the cardiovascular manifestations and no well-defined therapeutic strategies. We …

Redox stress is involved in the aortic aneurysm pathogenesis in Marfan syndrome (MFS). We
recently reported that allopurinol, a xanthine oxidoreductase inhibitor, blocked aortopathy …

The pathogenesis and progression of aortic aneurysm in Marfan syndrome (MFS) involves
dysregulated TGF-β and nitric oxide signaling, altered hemodynamics, and biomechanical …

Thoracic aortic aneurysm and dissection (TAAD) associates with a high mortality rate. Despite
the existence of different mouse models for TAAD, the underlying disease mechanisms …

Relación de Secretarios de tercera ca tegoría de Administración Local selec cionados para
su ingreso directo en los cursos de Habilitación para el Secreta riado de segunda categoría, …

Como bien sabéis, nuestros principales retos y objetivos en el CIBERER, alineados con el
Consorcio Internacional de Investigación en Enfermedades Raras (IRDiRC), son desarrollar …