Human induced pluripotent stem (iPS) cells hold great promise for advancements in
developmental biology, cell-based therapy, and modeling of human disease. Here, we examined …

Metabolic homeostasis emerges from the complex, multidirectional crosstalk between key
metabolic tissues including adipose tissue, liver, and skeletal muscle. This crosstalk, …

Obesity, insulin resistance and their attendant complications are among the leading causes
of morbidity and premature mortality today, yet we are only in the early stages of …

BACKGROUND & AIMS: Childhood obesity is a growing problem worldwide. Non-alcoholic
fatty liver disease (NAFLD) is frequently associated with obesity in children. Recently, the …

Background and objectives Non-alcoholic fatty liver disease (NAFLD) develops due to
impaired hepatic lipid fluxes and is a risk factor for chronic liver disease and atherosclerosis. …

Unravelling the pathogenesis of fatty liver disease: patatin... : Current Opinion in Lipidology
Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing …

Obesity-related insulin resistance is associated with fatty liver, dyslipidemia, and low plasma
adiponectin. Insulin resistance due to insulin receptor (INSR) dysfunction is associated with …

OBJECTIVE Genetic defects in human pericentrin (PCNT), encoding the centrosomal protein
pericentrin, cause a form of osteodysplastic primordial dwarfism that is sometimes reported …

Context Insulin resistance (IR) is associated with polycystic ovaries and hyperandrogenism,
but underpinning mechanisms are poorly understood and therapeutic options are limited. …

Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin
and HDL cholesterol concentrations, obesity, and coronary atherosclerosis. The ARL15 …