Background: Subjective cognitive decline (SCD) is gaining importance as a focus of
investigation, but adequate tools are needed for its quantification. Objective: To develop and …

Introduction Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a “Holy
Grail” of AD research and intensively sought; however, there are no well-established …

Objective To assess the relationships between core cerebrospinal fluid (CSF) biomarkers
and cortical thickness (CTh) in preclinical Alzheimer disease (AD). Methods In this cross‐…

Introduction Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed
biomarkers for Alzheimer's disease (AD). Methods We included healthy control subjects (N …

Background: Biomarkers in the cerebrospinal fluid (CSF) can track specific pathophysiological
pathways underlying Alzheimer’s disease (AD). The connection between these …

Background The APOE effect on Alzheimer Disease (AD) risk is stronger in women than in
men but its mechanisms have not been established. We assessed the APOE-by-sex …

Background Astrocytes play an essential role in neuroinflammation and are involved in the
pathogenesis of neurodenegerative diseases. Studies of glial fibrillary acidic protein (GFAP), …

Cerebrospinal fluid YKL-40 has been described as a marker of glial inflammation. We aimed
to study the relationship between YKL-40 and brain structure and its interactions with core …

Objective To investigate the clinical utility of 3 CSF biomarkers along the clinical spectrum of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Methods We …

Objective To evaluate pathological complete response as a surrogate endpoint for disease-free
survival and overall survival in regulatory neoadjuvant trials of early stage breast cancer. …