Early-life cues shape the immune system during adulthood. However, early-life signaling
pathways and their temporal functions are not well understood. Herein, we demonstrate that …

Initiation of adaptive immunity to particulate antigens in lymph nodes largely depends on
their presentation by migratory dendritic cells (DCs). DC subsets differ in their capacity to …

B lymphocyte‐induced maturation protein‐1 (Blimp‐1), the transcription factor encoded by
the gene Prdm1, plays a number of crucial roles in the adaptive immune system, which result …

Rotavirus (RV) infection induces strong adaptive immunity. While protection from reinfection
requires humoral immunity, initial clearance of infection depends on cytotoxic CD8 T cells. …

Viral triggers at the intestinal mucosa can have multiple global effects on intestinal integrity,
causing elevated intestinal barrier strength and relative protection from subsequent …

The cytokine IL-23 plays important roles in intestinal barrier protection and integrity, but is
also linked to chronic inflammation. In this issue of JEM, Ohara et al.(https://doi. org/10.1084/…

Conventional dendritic cells (cDC) play key roles in immune induction, but what drives their
heterogeneity and functional specialization is still ill-defined. Here we show that cDC-specific …

Dendritic cells express the transcriptional repressor Bcl6, but its precise role in the development
and function within the dendritic cell (DC) compartment has been heavily debated. Here …

RORγt + γδ T cells, known as γδT17, are an innate-like subset of T cells that produce
interleukin (IL)-17A and initiate type 3 immune responses during infections or autoimmune …

Dendritic cells express the transcriptional repressor Bcl6, but its precise role in the development
and function within the dendritic cell (DC) compartment has been heavily debated. Here …