The carotid body detects circulating tumor necrosis factor-alpha to activate a sympathetic anti-inflammatory reflex

PL Katayama, IP Leirão, A Kanashiro, JPM Luiz… - Brain, behavior, and …, 2022 - Elsevier
Recent evidence has suggested that the carotid bodies might act as immunological sensors,
detecting pro-inflammatory mediators and signalling to the central nervous system, which, …

[HTML][HTML] The carotid body: A novel key player in neuroimmune interactions

PL Katayama, IP Leirão, A Kanashiro… - Frontiers in …, 2022 - frontiersin.org
The idea that the nervous system communicates with the immune system to regulate
physiological and pathological processes is not new. However, there is still much to learn about …

Hypercapnia‐induced active expiration increases in sleep and enhances ventilation in unanaesthetized rats

IP Leirão, CA Silva Jr, LH Gargaglioni… - The Journal of …, 2018 - Wiley Online Library
… IP Leirão and CA Silva contributed equally to this study. … Animals were anaesthetized
with ketamine (100 mg kg −1 ; i.p.) and xylazine (15 mg kg −1 ; i.p.) to have the EMG and EEG …

Sympathetic dysregulation induced by postnatal intermittent hypoxia

M Karlen-Amarante, IP Leirão, PL Katayama… - Sleep, 2023 - academic.oup.com
Study Objectives Exposure to postnatal chronic intermittent hypoxia (pCIH), as experienced
in sleep-disordered breathing, is a risk factor for developing cardiorespiratory diseases in …

Hypoxia sensing in the body: An update on the peripheral and central mechanisms

…, LR Mendes, AB Evangelista, IP Leirão - Experimental …, 2023 - Wiley Online Library
… Evangelista and Isabela Paula Leirão provided intellectual input and designed the review. …
Evangelista and Isabela de Paula Leirão corrected and approved the final version of the …

Lesion of serotonergic afferents to the retrotrapezoid nucleus impairs the tachypneic response to hypercapnia in unanesthetized animals

IP Leirão, DSA Colombari, GSF da Silva, DB Zoccal - Neuroscience, 2021 - Elsevier
… Author links open overlay panel Isabela P. Leirão a , Débora SA Colombari a , Glauber SF
… These neurons compose the retrotrapeoid nucleus (RTN), express receptors for substance P

Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats

IP Leirão, DB Zoccal, LH Gargaglioni… - Pflügers Archiv-European …, 2020 - Springer
Active expiration represents an important mechanism to improve ventilation in conditions of
augmented ventilatory demand, such as hypercapnia. While a rostral ventromedullary region…

Genomic characterization of a novel SARS-CoV-2 lineage from Rio de Janeiro, Brazil

…, TS Frauches, CMB de Mello, IC Leitão… - Journal of …, 2021 - Am Soc Microbiol
… We downloaded all B.1.1.28, P.1, and P.2 high-coverage genomes available in GISAID on
… highlight P.1 and P.2 lineages. The aLRT support value for the branch holding P.1 and P.2 …

[HTML][HTML] R534C mutation in hERG causes a trafficking defect in iPSC-derived cardiomyocytes from patients with type 2 long QT syndrome

…, D Silva dos Santos, G Neiman, IC Leitão… - Scientific reports, 2019 - nature.com
Patient-specific cardiomyocytes obtained from induced pluripotent stem cells (CM-iPSC)
offer unprecedented mechanistic insights in the study of inherited cardiac diseases. The …

From a recombinant key antigen to an accurate, affordable serological test: Lessons learnt from COVID-19 for future pandemics

…, LM Higa, FL Monteiro, DPB Abreu, IC Leitão… - Biochemical …, 2022 - Elsevier
Serological tests detect antibodies generated by infection or vaccination, and are indispensable
tools along different phases of a pandemic, from early monitoring of pathogen spread up …