[PDF][PDF] Mutations in the glycosyltransferase domain of GLT8D1 are associated with familial amyotrophic lateral sclerosis
…, L Castelli, A Beer, H Robins, I Fox, I Niedermoser… - Cell reports, 2019 - cell.com
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder without effective
neuroprotective therapy. Known genetic variants impair pathways, including RNA …
neuroprotective therapy. Known genetic variants impair pathways, including RNA …
[HTML][HTML] Cnidarian-bilaterian comparison reveals the ancestral regulatory logic of the β-catenin dependent axial patterning
In animals, body axis patterning is based on the concentration-dependent interpretation of
graded morphogen signals, which enables correct positioning of the anatomical structures. …
graded morphogen signals, which enables correct positioning of the anatomical structures. …
[HTML][HTML] Targeted genetic screen in amyotrophic lateral sclerosis reveals novel genetic variants with synergistic effect on clinical phenotype
J Cooper-Knock, H Robins, I Niedermoser… - Frontiers in molecular …, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is underpinned by an oligogenic rare variant architecture.
Identified genetic variants of ALS include RNA-binding proteins containing prion-like …
Identified genetic variants of ALS include RNA-binding proteins containing prion-like …
Stress-induced clustering of the UPR sensor IRE1α is driven by disordered regions within its ER lumenal domain
…, E Spinetti, M Rechberger, P Radler, I Niedermoser… - BioRxiv, 2023 - biorxiv.org
Upon accumulation of unfolded proteins at the endoplasmic reticulum (ER), IRE1 activates
the unfolded protein response (UPR) to restore protein-folding homeostasis. During ER stress…
the unfolded protein response (UPR) to restore protein-folding homeostasis. During ER stress…
β-catenin dependent axial patterning in Cnidaria and Bilateria uses similar regulatory logic
In animals, body axis patterning is based on the concentration-dependent interpretation of
graded morphogen signals, which enables correct positioning of the anatomical structures. …
graded morphogen signals, which enables correct positioning of the anatomical structures. …
Sea anemone Frizzled receptors play partially redundant roles in oral-aboral axis patterning
I Niedermoser, T Lebedeva, G Genikhovich - Development, 2022 - journals.biologists.com
Canonical Wnt (cWnt) signalling is involved in a plethora of basic developmental processes
such as endomesoderm specification, gastrulation and patterning the main body axis. To …
such as endomesoderm specification, gastrulation and patterning the main body axis. To …
β-catenin-dependent endomesoderm specification appears to be a Bilateria-specific co-option
T Lebedeva, J Boström, D Mörsdorf, I Niedermoser… - bioRxiv, 2022 - biorxiv.org
Endomesoderm specification based on a maternal β-catenin signal and axial patterning by
interpreting a gradient of zygotic Wnt/β-catenin signalling was suggested to predate the split …
interpreting a gradient of zygotic Wnt/β-catenin signalling was suggested to predate the split …
Mutations in the Glycosyltransferase Domain of GLT8D1 Cause Amyotrophic Lateral Sclerosis
…, L Castelli, A Beer, H Robins, I Fox, I Niedermoser… - 2018 - papers.ssrn.com
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disorder without effective
neuroprotective therapy. Known genetic variants impair pathways including RNA processing…
neuroprotective therapy. Known genetic variants impair pathways including RNA processing…
The selfless mind: How prefrontal involvement in mentalizing with similar and dissimilar others shapes empathy and prosocial behavior
J Majdandžić, S Amashaufer, A Hummer… - Cognition, 2016 - Elsevier
Engaging in mentalizing, ie, reflecting on others’ thoughts, beliefs and feelings, is known to
facilitate later empathy and prosocial behavior. Activation in dorsomedial prefrontal (dmPFC) …
facilitate later empathy and prosocial behavior. Activation in dorsomedial prefrontal (dmPFC) …
Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype
Amyotrophic lateral sclerosis (ALS) is underpinned by an oligogenic rare variant architecture.
Identified genetic variants of ALS include RNA-binding proteins containing prion-like …
Identified genetic variants of ALS include RNA-binding proteins containing prion-like …