Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …

Autophagy has an important role in cellular homeostasis by degrading and recycling
cytotoxic components. Ubiquitination is known to target cargoes for autophagy; however, key …

Chemotherapy with platinum complexes is essential for clinical anticancer therapy. However,
due to side effects and drug resistance, further drug improvement is urgently needed. …

Due to their high kinetic inertness and consequently reduced side reactions with biomolecules,
Pt IV complexes are considered to define the future of anticancer platinum drugs. The …

While platinum-based chemotherapeutic agents have established themselves as indispensable
components of anticancer therapy, they are accompanied by a variety of side effects and …

For a variety of cancer types, platinum compounds are still among the best treatment options.
However, their application is limited by side effects and drug resistance. Consequently, …

Pt(II) complexes, such as cisplatin and oxaliplatin, are in widespread use as anticancer drugs.
Their use is limited by the toxic side effects and the ability of tumors to develop resistance …

The therapeutic efficacy of cisplatin and oxaliplatin depends on the balance between the
DNA damage induction and the DNA damage response of tumor cells. Based on clinical …

Tyrosine kinase inhibitors revolutionized cancer therapy but still evoke strong adverse effects
that can dramatically reduce patients’ quality of life. One possibility to enhance drug safety …

The Inhibitor of Apoptosis Protein (IAP) family members are well-known endogenous regulators
of apoptosis. Whether these proteins regulate other degradation pathways is unclear. …