Adipocyte-derived lipids mediate melanoma progression via FATP proteins
…, NR Campbell, SC Baksh, T Simon-Vermot, IS Kim… - Cancer discovery, 2018 - AACR
Advanced, metastatic melanomas frequently grow in subcutaneous tissues and portend a
poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the …
poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the …
[HTML][HTML] Microenvironment-derived factors driving metastatic plasticity in melanoma
IS Kim, S Heilmann, ER Kansler, Y Zhang… - Nature …, 2017 - nature.com
Cellular plasticity is a state in which cancer cells exist along a reversible phenotypic spectrum,
and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is …
and underlies key traits such as drug resistance and metastasis. Melanoma plasticity is …
A quantitative system for studying metastasis using transparent zebrafish
…, K Ratnakumar, EM Langdon, ER Kansler, IS Kim… - Cancer research, 2015 - AACR
Metastasis is the defining feature of advanced malignancy, yet remains challenging to study
in laboratory environments. Here, we describe a high-throughput zebrafish system for …
in laboratory environments. Here, we describe a high-throughput zebrafish system for …
[PDF][PDF] The stress-like cancer cell state is a consistent component of tumorigenesis
Transcriptional profiling of tumors has revealed a stress-like state among the cancer cells
with the concerted expression of genes such as fos, jun, and heat-shock proteins, though this …
with the concerted expression of genes such as fos, jun, and heat-shock proteins, though this …
Cancer modeling by transgene electroporation in adult zebrafish (TEAZ)
…, A Burger, NR Campbell, IS Kim… - Disease models & …, 2018 - journals.biologists.com
Transgenic animals are invaluable for modeling cancer genomics, but often require complex
crosses of multiple germline alleles to obtain the desired combinations. Zebrafish models …
crosses of multiple germline alleles to obtain the desired combinations. Zebrafish models …
A population of stress-like cancer cells in melanoma promotes tumorigenesis and confers drug resistance
Tumors evolve as independent systems comprising complex survival-ensuring functions,
however the nature of these distinct processes and their recurrence across cancers is not clear. …
however the nature of these distinct processes and their recurrence across cancers is not clear. …
[PDF][PDF] Cancer archetypes co-opt and adapt the transcriptional programs of existing cellular states
13 Tumors evolve as independent systems comprising complex survival-ensuring functions,
14 however the nature of these distinct processes and their recurrence across cancers is not …
14 however the nature of these distinct processes and their recurrence across cancers is not …
Cell state mapping reveals a role for a stress program in melanoma
M Baron, M Tagore, M Hunter, IS Kim, R Moncada… - Cancer Research, 2020 - AACR
Transcriptional profiling has revealed a diverse range of cell states in cancer, but the
function of these various states remains elusive. Using a combination of zebrafish melanoma …
function of these various states remains elusive. Using a combination of zebrafish melanoma …
Surgical treatment of intramedullary spinal cord metastases: functional outcome and complications—a multicenter study
…, S Telera, M Galarza, GM Callovini, S Isabella… - Neurosurgical …, 2021 - Springer
Intramedullary spinal cord metastasis (ISCM) is a rare event in the course of advanced
malignancy. Management of these lesions remains controversial. Recently, surgery for ISCM has …
malignancy. Management of these lesions remains controversial. Recently, surgery for ISCM has …
Mapping neural dynamics underlying saccade preparation and execution and their relation to reaction time and direction errors
Our ability to control and inhibit automatic behaviors is crucial for negotiating complex
environments, all of which require rapid communication between sensory, motor, and cognitive …
environments, all of which require rapid communication between sensory, motor, and cognitive …