Background Hox proteins are transcription factors involved in crucial processes during animal
development. Their mode of action remains scantily documented. While other families of …

10.7554/eLife.29312.001 Recent advances in single-cell transcriptomics techniques have
opened the door to the study of gene regulatory networks (GRNs) at the single-cell level. Here…

Hox proteins are conserved homeodomain transcription factors known to be crucial regulators
of animal development. As transcription factors, the functions and modes of action (co-…

Regulation of transcription factor activity relies on molecular interactions or enzymatic
modifications which influence their interaction with DNA cis-regulatory sequences, their …

Progress in the generation of Hematopoietic Stem and Progenitor Cells (HSPCs) in vitro and
ex vivo has been built on the knowledge of developmental hematopoiesis, underscoring …

The homeodomain transcription factor Hoxa2 interacts with the RING-finger type E3 ubiquitin
ligase RCHY1 and induces its proteasomal degradation. In this work, we dissected this non…

HOX proteins are homeodomain transcription factors critically involved in patterning animal
embryos and controlling organogenesis. While the functions of HOX proteins and the …

Introduction: Unmet needs exist for immunotherapy targeting PD-1/PD-L1 in head and neck
squamous cell carcinoma (HNSCC) and lung squamous cell carcinoma (LUSC) due to its …

The Endothelial to Hematopoietic Transition (EHT) constitutes an essential step in the formation
of hematopoietic progenitor and stem cells. However, it is still unclear whether there is a …

In vitro differentiation of mouse embryonic stem cells (mESCs) towards blood cells constitutes
a well-established system to study the endothelial-to-hematopoietic transition (EHT) at the …