Lamins are nuclear intermediate filaments that, together with lamin-associated proteins,
maintain nuclear shape and provide a structural support for chromosomes and replicating DNA. …

Lamins A and C are intermediate filament proteins which polymerize into the nucleus to
form the nuclear lamina network. The lamina is apposed to the inner nuclear membrane and …

Physiological processes are mainly controlled by intermolecular recognition mechanisms
involving protein–protein and protein–ligand (low molecular weight molecules) interactions. …

Fragment-based drug discovery is a strategy widely used in both academia and pharmaceutical
companies to generate small-molecule protein inhibitors and drug candidates. Among …

Cyclophilins are peptidyl-prolyl cis/trans isomerases (PPIase) that catalyse the interconversion
of the peptide bond at proline residues. Several cyclophilins play a pivotal role in the life …

Structural studies of integral membrane proteins have been limited by the intrinsic
conformational flexibility and the need to stabilize the proteins in solution. Stabilization by …

Fragment-based drug design consists of screening low-molecular-weight compounds in order
to identify low-affinity ligands that are then modified or linked to yield potent inhibitors. The …

While saturation transfer difference (STD) is a widely used NMR method for ligand screening,
the selection of specific binders requires the validation of the hits through competition …

WaterLOGSY is a sensitive ligand-observed NMR experiment for detection of interaction
between a ligand and a protein and is now well-established as a screening technique for …

Introduction In fragment-based drug design, fragment linking is a popular strategy where
two fragments binding to different sub-pockets of a target are linked together. This attractive …