Chronic exposure to excess glucocorticoids results in cognitive and psychological impairment.
A few studies have indicated that cerebral atrophy can be found in patients with Cushing’…

AMPK (5′-AMP-activated protein kinase) is emerging as a metabolic master switch, by which
cells in both mammals and lower organisms sense and decode changes in energy status. …

AMP-activated protein kinase (AMPK) has recently been implicated in the control of
preproinsulin gene expression in pancreatic islet β-cells [da Silva Xavier, Leclerc, Salt, Doiron, …

Elevated glucose concentrations stimulate the transcription of the pre-proinsulin (PPI), L-type
pyruvate kinase (L-PK), and other genes in islet beta cells. In liver cells, pharmacological …

Mutations in the HNF4α gene are responsible for type 1 maturity-onset diabetes of the young
(MODY1), which is characterized by a defect in insulin secretion. Hepatocyte nuclear factor (…

Metformin, a drug widely used in the treatment of type 2 diabetes, has recently been shown
to act on skeletal muscle and liver in part through the activation of AMP-activated protein …

Transient neonatal diabetes mellitus (TNDM) is a rare inherited diabetic syndrome apparent
in the first weeks of life and again during early adulthood. The relative contributions of …

Pancreatic β-cells form highly connected networks within isolated islets. Whether this behaviour
pertains to the situation in vivo, after innervation and during continuous perfusion with …

We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing
2,973 individuals across three molecular classes, metabolites, lipids and proteins. …

Changes in 5′-AMP-activated protein kinase (AMPK) activity have recently been implicated
in the control of insulin secretion by glucose (da Silva Xavier, G., Leclerc, I., Varadi, A., …