Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying
mechanisms are poorly understood. We describe an mTOR-driven mouse model that displays …

The plasma membrane delimits the cell, and its integrity is essential for cell survival. Lipids
and proteins form domains of distinct composition within the plasma membrane. How …

Oxygen deprivation is rapidly deleterious for most organisms. However, Caenorhabditis
elegans has developed the ability to survive anoxia for at least 48 hours. Mutations in the DAF-2/…

The high sterol concentration in eukaryotic cell membranes is thought to influence membrane
properties such as permeability, fluidity and microdomain formation. Drosophila cannot …

Lipid mobilization through fatty acid β-oxidation is a central process essential for energy
production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome …

The endoplasmic reticulum (ER)–mitochondrial encounter structure (ERMES) physically
links the membranes of the ER and mitochondria in yeast. Although the ER and mitochondria …

Sterols are major lipids in eukaryotes and differ in their specific structure between species.
Both cholesterol and ergosterol can form liquid ordered domains in artificial membranes. We …

The systematic and quantitative analysis of the different lipid species within a cell or an
organism has recently become possible and the general approach has been termed “lipidomics.” …

The endoplasmic reticulum (ER) is a large, multifunctional and essential organelle. Despite
intense research, the function of more than a third of ER proteins remains unknown even in …

Sphingolipids are membrane lipids globally required for eukaryotic life. The sphingolipid
content varies among endomembranes with pre‐ and post‐Golgi compartments being poor and …