Background— Master regulators of protein synthesis such as mammalian target of rapamycin
(mTOR) and p70S6 kinase contribute to left ventricular hypertrophy. These prohypertrophic …

In addition to fatty acids, glucose and lactate are important myocardial substrates under
physiologic and stress conditions. They are metabolized to pyruvate, which enters mitochondria …

Because recent evidence demonstrated that calorie restriction (CR) has numerous beneficial
cardiovascular effects, we investigated whether short-term CR could reduce hypertension …

Consumption of ω-3 fatty acids from fish oil, specifically eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA), decreases risk for heart failure and attenuates pathologic …

Essentially all biological processes fluctuate over the course of the day, manifesting as time-of-day-dependent
variations with regards to the way in which organ systems respond to …

The goal of this work was to develop a label-free, comprehensive, and reproducible high-resolution
liquid chromatography–mass spectrometry (LC-MS)-based untargeted lipidomic …

Mitochondrial dysfunction characterizes many rare and common age-associated diseases.
The biochemical consequences, underlying clinical manifestations, and potential therapeutic …

High plasma leucine levels strongly correlate with type 2 diabetes. Studies of muscle cells
have suggested that leucine alters the insulin response for glucose transport by activating an …

Supplementation with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from
fish oil may prevent development of heart failure through alterations in cardiac phospholipids …

Very-long chain acyl-CoA dehydrogenase (VLCAD) catalyzes the initial step of
mitochondrial long chain (LC) fatty acid β-oxidation (FAO). Inherited VLCAD deficiency (VLCADD) …