User profiles for Isabelle Stévant
 | Isabelle StévantBar Ilan University Verified email at biu.ac.il Cited by 1835 |
[PDF][PDF] Dissecting cell lineage specification and sex fate determination in gonadal somatic cells using single-cell transcriptomics
I Stévant, F Kühne, A Greenfield, MC Chaboissier… - Cell reports, 2019 - cell.com
Sex determination is a unique process that allows the study of multipotent progenitors and
their acquisition of sex-specific fates during differentiation of the gonad into a testis or an ovary…
their acquisition of sex-specific fates during differentiation of the gonad into a testis or an ovary…
[PDF][PDF] Deciphering cell lineage specification during male sex determination with single-cell RNA sequencing
The gonad is a unique biological system for studying cell-fate decisions. However, major
questions remain regarding the identity of somatic progenitor cells and the transcriptional …
questions remain regarding the identity of somatic progenitor cells and the transcriptional …
Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex
During corticogenesis, excitatory neurons are born from progenitors located in the ventricular
zone (VZ), from where they migrate to assemble into circuits. How neuronal identity is …
zone (VZ), from where they migrate to assemble into circuits. How neuronal identity is …
A brief history of sex determination
A fundamental biological question that has puzzled, but also fascinated mankind since antiquity
is the one pertaining to the differences between sexes. Ancient cultures and mythologies …
is the one pertaining to the differences between sexes. Ancient cultures and mythologies …
[HTML][HTML] Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements
There are ∼650,000 Alu elements in transcribed regions of the human genome. These elements
contain cryptic splice sites, so they are in constant danger of aberrant incorporation into …
contain cryptic splice sites, so they are in constant danger of aberrant incorporation into …
Genetic control of gonadal sex determination and development
Sex determination is the process by which the bipotential gonads develop as either testes or
ovaries. With two distinct potential outcomes, the gonadal primordium offers a unique model …
ovaries. With two distinct potential outcomes, the gonadal primordium offers a unique model …
Research resource: the dynamic transcriptional profile of sertoli cells during the progression of spermatogenesis
Sertoli cells (SCs), the only somatic cells within seminiferous tubules, associate intimately
with developing germ cells. They not only provide physical and nutritional support but also …
with developing germ cells. They not only provide physical and nutritional support but also …
ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling
Mammalian sex determination is controlled by the antagonistic interactions of two genetic
pathways: The SRY-SOX9-FGF9 network promotes testis determination partly by opposing …
pathways: The SRY-SOX9-FGF9 network promotes testis determination partly by opposing …
Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad
…, D Condrea, F Kühne, I Gantar, F Tang, I Stévant… - Science …, 2022 - science.org
Gonadal sex determination represents a unique model for studying cell fate decisions.
However, a complete understanding of the different cell lineages forming the developing testis …
However, a complete understanding of the different cell lineages forming the developing testis …
Characterizing the bipotential mammalian gonad
Primary sex determination is the decision by which the bipotential embryonic gonad commits
to either the testicular or ovarian fate. The developing gonad constitutes a unique paradigm …
to either the testicular or ovarian fate. The developing gonad constitutes a unique paradigm …